Shaforostova Inna, Fiedler Robert, Zander Martina, Pflumm Johannes, März Wolfgang Josef
Department of Haematology, Haemostasiology, Oncology and Pneumology, Albert-Schweitzer Campus 1, Muenster, Germany.
Department of Radiology, Hospital Harzklinikum Dorothea Christiane Erxleben GmbH, Wernigerode, Germany.
Case Rep Gastroenterol. 2020 May 7;14(2):255-260. doi: 10.1159/000507648. eCollection 2020 May-Aug.
Tumor lysis syndrome (TLS) is a potentially life-threatening complication of chemotherapy. It usually occurs in rapidly proliferating hematological malignancies. TLS is deemed spontaneous (STLS) when it occurs prior to any cytotoxic or definite treatment. STLS is extremely rare in solid tumors. Here, we report a rare case of fatal STLS in a 47-year-old woman diagnosed with metastatic colon cancer. The patient developed acute renal failure with anuria, electrolyte disturbances, and metabolic acidosis before initiating chemotherapy. Despite appropriate management of TLS, including renal replacement therapy, she died within a few days from multiorgan failure. Only few other case reports of STLS associated with colon cancer have been reported in the literature.
肿瘤溶解综合征（TLS）是化疗一种潜在的危及生命的并发症。它通常发生在快速增殖的血液系统恶性肿瘤中。当TLS在任何细胞毒性或确定性治疗之前发生时，被视为自发性肿瘤溶解综合征（STLS）。STLS在实体瘤中极为罕见。在此，我们报告一例罕见的致命性STLS病例，患者为一名47岁被诊断为转移性结肠癌的女性。该患者在开始化疗前出现急性肾衰竭伴无尿、电解质紊乱和代谢性酸中毒。尽管对TLS进行了适当处理，包括肾脏替代治疗，但她在几天内死于多器官功能衰竭。文献中仅报道了其他少数几例与结肠癌相关的STLS病例报告。
