Pulido Fontes L, Quesada Jimenez P, Mendioroz Iriarte M
Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España; Navarrabiomed, Pamplona, Navarra, España.
Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España.
Neurologia. 2015 Mar;30(2):111-8. doi: 10.1016/j.nrl.2014.03.012. Epub 2014 May 19.
Epigenetics is the study of heritable modifications in gene expression that do not change the DNA nucleotide sequence. Some of the most thoroughly studied epigenetic mechanisms at present are DNA methylation, post-transcriptional modifications of histones, and the effect of non-coding RNA molecules. Gene expression is regulated by means of these mechanisms and disruption of these molecular pathways may elicit development of diseases.
We describe the main epigenetic regulatory mechanisms and review the most recent literature about epigenetic mechanisms and how those mechanisms are involved in different epileptic syndromes.
Identifying the epigenetic mechanisms involved in epilepsy is a promising line of research that will deliver more in-depth knowledge of epilepsy pathophysiology and treatments.
表观遗传学是对基因表达中可遗传修饰的研究，这些修饰不会改变DNA核苷酸序列。目前一些研究最为深入的表观遗传机制包括DNA甲基化、组蛋白的转录后修饰以及非编码RNA分子的作用。基因表达通过这些机制进行调控，而这些分子途径的破坏可能引发疾病的发展。
我们描述了主要的表观遗传调控机制，并回顾了有关表观遗传机制以及这些机制如何参与不同癫痫综合征的最新文献。
确定参与癫痫的表观遗传机制是一个有前景的研究方向，将为癫痫的病理生理学和治疗提供更深入的认识。
