Deo Salil V, Rababa'h Abeer, Altarabsheh Salah E, Lim Ju Yong, Cho Yang Hyun, Park Soon J
Adventist Wockhardt Heart Institute, Surat Gujarat India.
Jordan University of Science and Technology, Irbid Jordan.
Heart Lung Circ. 2014 Oct;23(10):985-7. doi: 10.1016/j.hlc.2014.04.007. Epub 2014 Apr 18.
Statin therapy has demonstrated a beneficial effect in patients with chronic heart failure. While the majority of patients with ischaemic cardiomyopathy are prescribed these drugs, studies have demonstrated that less than one fifth of patients with dilated cardiomyopathy are on regular statin therapy. We have performed a meta-analysis of 4500 patients from six studies (four randomised controlled trials). Our results demonstrate that statin therapy significantly improves long-term survival in patients with non-ischaemic heart failure {Hazard ratio for mortality 0.45 (0.33-0.62); p<0.0001; I(2)=41%; p-value for heterogeneity=0.13}.
他汀类药物治疗已在慢性心力衰竭患者中显示出有益效果。虽然大多数缺血性心肌病患者都被开了这些药物，但研究表明，扩张型心肌病患者中接受常规他汀类药物治疗的不到五分之一。我们对六项研究（四项随机对照试验）中的4500名患者进行了荟萃分析。我们的结果表明，他汀类药物治疗可显著提高非缺血性心力衰竭患者的长期生存率{死亡风险比为0.45（0.33 - 0.62）；p<0.0001；I(2)=41%；异质性p值=0.13}。
