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Targeting Cholesterol in Non-ischemic Heart Failure: A Role for LDLR Gene Therapy?

作者信息

Catapano Alberico Luigi, Pirillo Angela, Norata Giuseppe Danilo

机构信息

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy; IRCCS Multimedica Hospital, Sesto San Giovanni, Milan, Italy.

IRCCS Multimedica Hospital, Sesto San Giovanni, Milan, Italy; Center for the Study of Atherosclerosis, E. Bassini Hospital, Cinisello Balsamo, Milan, Italy.

出版信息

Mol Ther. 2017 Nov 1;25(11):2435-2437. doi: 10.1016/j.ymthe.2017.10.008. Epub 2017 Oct 19.

DOI:10.1016/j.ymthe.2017.10.008
PMID:29056399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5675606/
Abstract
摘要

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本文引用的文献

1
Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice.降脂基因疗法可逆转小鼠非缺血性心肌病的发生。
Mol Ther. 2017 Nov 1;25(11):2513-2525. doi: 10.1016/j.ymthe.2017.07.017. Epub 2017 Aug 1.
2
Statins attenuate but do not eliminate the reverse epidemiology of total serum cholesterol in patients with non-ischemic chronic heart failure.
Int J Cardiol. 2017 Jul 1;238:97-104. doi: 10.1016/j.ijcard.2017.03.028. Epub 2017 Mar 9.
3
Association Between Use of Statins and Mortality in Patients With Heart Failure and Ejection Fraction of ≥50.射血分数≥50%的心力衰竭患者使用他汀类药物与死亡率之间的关联
Circ Heart Fail. 2015 Sep;8(5):862-70. doi: 10.1161/CIRCHEARTFAILURE.115.002143. Epub 2015 Aug 4.
4
Association between use of statins and outcomes in heart failure with reduced ejection fraction: prospective propensity score matched cohort study of 21 864 patients in the Swedish Heart Failure Registry.射血分数降低的心力衰竭患者使用他汀类药物与预后的关联：瑞典心力衰竭登记处21864例患者的前瞻性倾向评分匹配队列研究
Circ Heart Fail. 2015 Mar;8(2):252-60. doi: 10.1161/CIRCHEARTFAILURE.114.001730. Epub 2015 Jan 9.
5
Effect of rosuvastatin on repeat heart failure hospitalizations: the CORONA Trial (Controlled Rosuvastatin Multinational Trial in Heart Failure).**译文**： 氯吡格雷在减少缺血性事件方面优于安慰剂：CURE 试验（氯吡格雷在急性冠脉综合征患者中的疗效和安全性研究）。
JACC Heart Fail. 2014 Jun;2(3):289-97. doi: 10.1016/j.jchf.2013.12.007. Epub 2014 Apr 30.
6
Statin therapy improves long-term survival in non-ischaemic cardiomyopathy: a pooled analysis of 4500 patients.他汀类药物治疗可改善非缺血性心肌病患者的长期生存率：对4500例患者的汇总分析。
Heart Lung Circ. 2014 Oct;23(10):985-7. doi: 10.1016/j.hlc.2014.04.007. Epub 2014 Apr 18.
7
Long-term clinical outcomes of statin use for chronic heart failure: a meta-analysis of 15 prospective studies.他汀类药物治疗慢性心力衰竭的长期临床结局：15 项前瞻性研究的荟萃分析。
Heart Lung Circ. 2014 Feb;23(2):105-13. doi: 10.1016/j.hlc.2013.07.012. Epub 2013 Aug 17.
8
Rosuvastatin added to standard heart failure therapy improves cardiac remodelling in heart failure rats with preserved ejection fraction.瑞舒伐他汀联合标准心力衰竭治疗可改善射血分数保留心力衰竭大鼠的心脏重构。
Eur J Heart Fail. 2010 Sep;12(9):903-12. doi: 10.1093/eurjhf/hfq101. Epub 2010 Jul 2.
9
Low-density lipoprotein in the setting of congestive heart failure: is lower really better?充血性心力衰竭情况下的低密度脂蛋白：越低真的越好吗？
Curr Atheroscler Rep. 2009 Sep;11(5):343-9. doi: 10.1007/s11883-009-0052-4.
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Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy.他汀类药物用于缺血性和非缺血性心肌病患者的实验及临床依据。
J Am Coll Cardiol. 2008 Jan 29;51(4):415-26. doi: 10.1016/j.jacc.2007.10.009.