从红海软珊瑚灰肉参中分离得到的三种新的西松烷型二萜：及其对肝癌细胞HepG2的增殖抑制活性

Three new cembranoid-type diterpenes from Red Sea soft coral Sarcophyton glaucum: isolation and antiproliferative activity against HepG2 cells.

作者信息

Al-Lihaibi Sultan S, Alarif Walied M, Abdel-Lateff Ahmed, Ayyad Seif-Eldin N, Abdel-Naim Ashraf B, El-Senduny Fardous F, Badria Farid A

机构信息

Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P.O. Box 80207, Jeddah 21589, Saudi Arabia.

Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

出版信息

Eur J Med Chem. 2014 Jun 23;81:314-22. doi: 10.1016/j.ejmech.2014.05.016. Epub 2014 May 5.

DOI:10.1016/j.ejmech.2014.05.016

PMID:24852278

Abstract

Three new cembranoids: sarcophytolol (1), sarcophytolide B (2), and sarcophytolide C (3), along with three known metabolites: 10(14)aromadendrene (4), deoxosarcophine (5), and sarcophine (6) were obtained from the soft bodied coral Sarcophyton glaucum. The structures were determined based on spectroscopic measurements (NMR, UV, IR and MS). Compounds 1, 3, and 4 had similar significant cytotoxic effects towards HepG2 (Human hepatocellular liver carcinoma; IC50 = 20 μM). 2 and 3 showed activity against MCF-7 (Human breast adenocarcinoma; IC50 25 ± 0.0164 and 29 ± 0.030 μM, respectively). Finally, 4 showed potent activity towards PC-3 (Prostate cancer; IC50 9.3 ± 0.164 μM). The antiproliferative activity of 1, 3 and 4, can be attributed, at least partly, to their ability to induce cellular apoptosis.

摘要

从软珊瑚肉芝软珊瑚中获得了三种新的西松烷型二萜

肉芝醇（1）、肉芝内酯B（2）和肉芝内酯C（3），以及三种已知的代谢产物：10(14)-芳樟烯（4）、脱氧肉芝碱（5）和肉芝碱（6）。通过光谱测量（核磁共振、紫外、红外和质谱）确定了它们的结构。化合物1、3和4对肝癌细胞系HepG2具有相似的显著细胞毒性作用（半数抑制浓度IC50 = 20 μM）。化合物2和3对人乳腺癌细胞系MCF-7具有活性（IC50分别为25 ± 0.0164和29 ± 0.030 μM）。最后，化合物4对前列腺癌细胞系PC-3具有较强活性（IC50为9.3 ± 0.164 μM）。化合物1、3和4的抗增殖活性至少部分可归因于它们诱导细胞凋亡的能力。