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铜催化的通过交叉脱氢偶联的 C(sp3)-H 活化的烷基苯与环状醚和环烷烃的酯化反应。

Copper-catalyzed esterification of alkylbenzenes with cyclic ethers and cycloalkanes via C(sp3)-H activation following cross-dehydrogenative coupling.

机构信息

Department of Chemistry, Indian Institute of Technology Guwahati , North Guwahati 781039, India.

出版信息

Org Lett. 2014 Jun 6;16(11):3086-9. doi: 10.1021/ol5011906. Epub 2014 May 22.

DOI:10.1021/ol5011906
PMID:24852383
Abstract

A copper-catalyzed cross-dehydrogenative coupling strategy has been developed for the synthesis of two classes of esters from simple solvents. The reaction of methylarenes with cyclic ethers resulted in α-acyloxy ethers involving four sp(3) C-H cleavages, while treatment of methylarenes with cycloalkanes led to the formation of allyl esters at the expense of six consecutive sp(3) C-H bonds.

摘要

一种铜催化的交叉脱氢偶联策略已被开发用于从简单溶剂中合成两类酯。甲基芳烃与环醚反应生成涉及四个 sp(3) C-H 断裂的 α-烷氧基醚，而甲基芳烃与环烷烃反应则在消耗六个连续的 sp(3) C-H 键的情况下生成烯丙酯。

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