Vanagt Ward Y, Cools Björn, Boshoff Derize E, Frerich Stefan, Heying Ruth, Troost Els, Louw Jacoba, Eyskens Benedicte, Budts Werner, Gewillig Marc
Department of Congenital and Pediatric Cardiology, University Hospital Gasthuisberg, Leuven, Belgium; Department of Pediatrics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University Medical Center MUMC, Maastricht, The Netherlands; Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University Medical Center MUMC, Maastricht, The Netherlands.
Department of Congenital and Pediatric Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
Int J Cardiol. 2014 Jul 15;175(1):102-7. doi: 10.1016/j.ijcard.2014.04.271. Epub 2014 May 9.
Controversy remains regarding the use of covered stents in congenital heart disease (CHD). We evaluate the possibilities and safety of covered Cheatham-Platinum (CCP) stents in CHD.
Single-center retrospective CHD-database study of all CCP stents, 2003-2012. Three study groups: aortic coarctation (CoA), right ventricular outflow tract pre-stenting for percutaneous revalvulation (RVOT), and miscellaneous. Continuous data expressed as median (range).
114 CCP stents in 105 patients, age 16.8 years (4.2-71.2). CoA group: 54 CCP stents in 51 patients: 3/54 for aneurysm exclusion, in 51/54 covering used "prophylactically" because of increased risk for vessel tear. Overall, CCP stenting increased the coarctation diameter from 6mm (0-15) to 15 mm (10-20) (p<0.001). RVOT group: 39 CCP stents in 37 patients (34 with RVOT graft, 3 with transannular patch): the graft lumen had shrunken from nominal 21 mm (10-26) to 13 mm (5-22); with the CCP stent the RVOT was redilated to 22 mm (16-26, p<0.001 vs stenosis). Miscellaneous group: 21 CCP stents in 17 patients: closure of Fontan-circuit fenestration (n=5), restoration of superior caval vein (n=2) or pulmonary artery (n=3) patency, relief of supra-pulmonary stenosis (n=2), exclusion of aberrant pulmonary arteries (n=1), cavopulmonary conduit expansion (n=2), Blalock-Taussig shunt flow reduction (n=1), and defibrillator lead protection from sharp stents (n=1). Hybrid procedures performed in 3/17 patients. CCP stent was used as rescue treatment in 2/patients to seal iatrogenic bleeding.
CCP stents can safely be applied in CHD patients. The covering allows adequate sealing of existing or expected tears, thereby increasing the safety margin with more complete dilation.
关于覆膜支架在先天性心脏病(CHD)中的应用仍存在争议。我们评估了覆膜Cheatham-Platinum(CCP)支架在CHD中的应用可能性及安全性。
对2003年至2012年期间所有CCP支架进行单中心回顾性CHD数据库研究。分为三个研究组:主动脉缩窄(CoA)组、经皮再瓣膜置换术前右心室流出道预支架置入(RVOT)组和其他组。连续数据以中位数(范围)表示。
105例患者置入114枚CCP支架,年龄16.8岁(4.2 - 71.2岁)。CoA组:51例患者置入54枚CCP支架,其中3枚用于排除动脉瘤,51枚中因血管撕裂风险增加“预防性”使用覆膜。总体而言,CCP支架置入使缩窄直径从6mm(0 - 15)增加到15mm(10 - 20)(p<0.001)。RVOT组:37例患者置入39枚CCP支架(34例有RVOT移植物,3例有跨环补片),移植物管腔直径从标称的21mm(10 - 26)缩小至13mm(5 - 22),使用CCP支架后RVOT再扩张至22mm(16 - 26,与狭窄相比p<0.001)。其他组:17例患者置入21枚CCP支架,包括封堵Fontan循环开窗(n = 5)、恢复上腔静脉(n = 2)或肺动脉(n = 3)通畅、缓解肺上狭窄(n = 2)、排除异常肺动脉(n = 1)、腔肺导管扩张(n = 2)、减少Blalock-Taussig分流(n = 1)以及保护除颤器导线免受尖锐支架损伤(n = 1)。17例患者中有3例进行了杂交手术。2例患者使用CCP支架作为挽救治疗以封闭医源性出血。
CCP支架可安全应用于CHD患者。覆膜可充分封闭现有或预期的撕裂,从而在更完全扩张的情况下增加安全边际。