Kumasaka Akira, Iikubo Masahiro, Nishioka Takashi, Kojima Ikuho, Shoji Noriaki, Sakamoto Maya, Sasano Takashi
Department of Oral Diagnosis, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Clin Implant Dent Relat Res. 2015 Dec;17(6):1174-9. doi: 10.1111/cid.12227. Epub 2014 May 22.
Alveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these extraction sites.
To investigate the longitudinal morphological changes in extraction sockets following sustained continuous subcutaneous infusion of human recombinant insulin-like growth factor I (IGF-I).
Fourteen rats were subjected to right mandibular first molar extraction. Experimental rats (n = 7) received a continuous subcutaneous infusion of human recombinant IGF-I (320 mg/day) for 3 weeks by osmotic minipump. Control animals were treated with saline via the same method (n = 7). All rats were then housed for an additional 3 weeks. Micro-CT scanning was performed immediately after tooth extraction and at 1, 2, 3, and 6 weeks after extraction.
New bone formation was markedly higher in the IGF-I-treated group as compared with the control group. The loss in alveolar ridge height in the IGF-I group was significantly lower than that in the control group at each time point after extraction on the buccal side and at 2, 3, and 6 weeks on the lingual side.
IGF-I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction.
拔牙后牙槽骨常发生吸收。很少有研究评估这些拔牙位点内骨体积的纵向变化。
研究持续皮下输注重组人胰岛素样生长因子I（IGF-I）后拔牙创的纵向形态学变化。
14只大鼠接受右侧下颌第一磨牙拔除术。实验大鼠（n = 7）通过渗透微型泵连续皮下输注重组人IGF-I（320 mg/天），持续3周。对照组动物以相同方法给予生理盐水（n = 7）。然后所有大鼠再饲养3周。在拔牙后即刻以及拔牙后1、2、3和6周进行显微CT扫描。
与对照组相比，IGF-I治疗组的新骨形成明显更多。IGF-I组拔牙后各时间点颊侧牙槽嵴高度的降低以及舌侧在拔牙后2、3和6周时牙槽嵴高度的降低均显著低于对照组。
IGF-I治疗可增加拔牙后新形成骨的体积，并减少牙槽嵴高度的降低。
