King Saud University, Department of Physics and Astronomy, Riyadh 11451, Kingdom of Saudi ArabiabUniversity of Madras, Department of Nuclear Physics, Chennai 600005, India.
King Saud University, Department of Physics and Astronomy, Riyadh 11451, Kingdom of Saudi Arabia.
J Biomed Opt. 2014 May;19(5):057011. doi: 10.1117/1.JBO.19.5.057011.
Fluorescence spectral techniques are very sensitive, and hence they are gaining importance in cancer detection. The biomarkers indicative of cancer could be identified and quantified by spectral or time domain fluorescence spectroscopy. The results of an investigation of time-resolved spectra of cellular components of blood obtained from cervical cancer patients and normal controls are given. The cancer indicative biomarker in this paper is porphyrin; it has a fluorescence decay time of 60% more in samples of cancer patients than those of normal controls. Based on such measurements, a randomized set comprising samples from cancer patients and controls (N=27 in total) could be classified with sensitivity (92%) and specificity (86%).
荧光光谱技术非常灵敏，因此在癌症检测方面越来越重要。通过光谱或时域荧光光谱学可以识别和定量癌症的生物标志物。本文给出了对宫颈癌患者和正常对照组血液细胞成分的时间分辨光谱进行研究的结果。本文中的癌症指示生物标志物是卟啉，它在癌症患者样本中的荧光衰减时间比正常对照组长 60%。基于这些测量结果，一组随机的包含癌症患者和对照者的样本（共 27 个样本）可以被分类，其灵敏度为 92%，特异性为 86%。
