Juarez-Molina Claudia I, Valenzuela-Ponce Humberto, Avila-Rios Santiago, Garrido-Rodriguez Daniela, Garcia-Tellez Thalía, Soto-Nava Maribel, Garcia-Morales Claudia, Goulder Philip, Reyes-Teran Gustavo
aDepartment of Paediatrics, University of Oxford, Oxford, UK bCentre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico. *Claudia I. Juarez-Molina and Humberto Valenzuela-Ponce contributed equally to the writing of this article.
AIDS. 2014 Jul 17;28(11):1687-90. doi: 10.1097/QAD.0000000000000322.
HLA-B35 has consistently been associated with rapid HIV disease progression, particularly alleles of the Px group. As B35 is the most prevalent HLA-B in Mexico, we investigated HIV disease outcome in relation to HLA expression in a large cohort (n=976) of Mexicans. Contrary to the previous studies, no impact on viral load or CD4 cell count was observed in association with the B35 PY/Px groups. However, we observed differences in HIV disease outcome associated with specific HLA-B35 alleles.
HLA - B35一直与HIV疾病的快速进展相关，尤其是Px组的等位基因。由于B35是墨西哥最常见的HLA - B，我们在一个大型墨西哥人群队列（n = 976）中研究了与HLA表达相关的HIV疾病转归。与先前的研究相反，未观察到B35 PY/Px组与病毒载量或CD4细胞计数之间存在关联。然而，我们观察到与特定HLA - B35等位基因相关的HIV疾病转归存在差异。
