钯催化2-氨基苯甲腈与芳基亚磺酸钠的直接加成反应：邻氨基二苯甲酮的合成
Palladium-catalyzed direct addition of 2-aminobenzonitriles to sodium arylsulfinates: synthesis of o-aminobenzophenones.
作者信息
Chen Jiuxi, Li Jianjun, Su Weike
机构信息
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
出版信息
Molecules. 2014 May 20;19(5):6439-49. doi: 10.3390/molecules19056439.
The first example of the palladium-catalyzed synthesis of o-aminobenzophenones in moderate to excellent yields via a direct addition of sodium arylsulfinates to unprotected 2-aminobenzonitriles was reported. A plausible mechanism for the formation of o-aminobenzophenones involving desulfination and addition reactions was proposed. The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of o-aminobenzophenones.
据报道，通过将芳基亚磺酸钠直接加成到未保护的2-氨基苯腈上，以中等至优异的产率钯催化合成邻氨基二苯甲酮的首个实例。提出了一种涉及脱硫和加成反应的邻氨基二苯甲酮形成的合理机理。这种转化的实用性通过其与多种官能团的相容性得到了证明。因此，该方法代表了一种方便实用的邻氨基二苯甲酮合成策略。
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