Department of Neuroscience and Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA.
Department of Neuroscience and Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA.
Neuron. 2014 May 21;82(4):896-907. doi: 10.1016/j.neuron.2014.03.025.
The capacity to predict the sensory consequences of movements is critical for sensory, motor, and cognitive function. Though it is hypothesized that internal signals related to motor commands, known as corollary discharge, serve to generate such predictions, this process remains poorly understood at the neural circuit level. Here we demonstrate that neurons in the electrosensory lobe (ELL) of weakly electric mormyrid fish generate negative images of the sensory consequences of the fish's own movements based on ascending spinal corollary discharge signals. These results generalize previous findings describing mechanisms for generating negative images of the effects of the fish's specialized electric organ discharge (EOD) and suggest that a cerebellum-like circuit endowed with associative synaptic plasticity acting on corollary discharge can solve the complex and ubiquitous problem of predicting sensory consequences of movements.
预测运动感觉后果的能力对感觉、运动和认知功能至关重要。虽然人们假设与运动指令相关的内部信号，即所谓的伴随放电，有助于产生这种预测，但这一过程在神经回路水平上仍知之甚少。在这里，我们证明电鳗鱼的电感觉叶（ELL）中的神经元根据上升的脊髓伴随放电信号，产生鱼自身运动的感觉后果的负像。这些结果推广了先前描述用于产生鱼特殊电器官放电（EOD）效应负像的机制的发现，并表明具有联想突触可塑性的小脑样电路作用于伴随放电，可以解决预测运动感觉后果的复杂和普遍问题。
