Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Institut National de la Santé et de la Recherche Médicale U1104, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7280, 13288 Marseille, France.
Nat Rev Immunol. 2014 Jun;14(6):417-28. doi: 10.1038/nri3683.
Immune cell populations in the skin are predominantly comprised of dendritic cells (DCs) and macrophages. A lack of consensus regarding how to define these cell types has hampered research in this area. In this Review, we focus on recent advances that, based on ontogeny and global gene-expression profiles, have succeeded in discriminating DCs from macrophages in the skin. We discuss how these studies have enabled researchers to revisit the origin, diversity and T cell-stimulatory properties of these cells, and have led to unifying principles that extend across tissues and species. By aligning the DC and macrophage subsets that are found in mouse skin with those that are present in human skin, these studies also provide crucial information for developing intradermal vaccines and for managing inflammatory skin conditions.
皮肤中的免疫细胞群体主要由树突状细胞 (DC) 和巨噬细胞组成。由于缺乏共识，如何定义这些细胞类型一直阻碍着该领域的研究。在这篇综述中，我们重点介绍了基于个体发生和全局基因表达谱的最新进展，这些进展成功地区分了皮肤中的 DC 和巨噬细胞。我们讨论了这些研究如何使研究人员能够重新审视这些细胞的起源、多样性和 T 细胞刺激特性，并导致跨组织和物种的统一原则。通过将在小鼠皮肤中发现的 DC 和巨噬细胞亚群与在人类皮肤中存在的亚群进行匹配，这些研究还为开发皮内疫苗和管理炎症性皮肤疾病提供了重要信息。
