Kim Nam-Hee, Sim So-Jin, Han Hong-Gyu, Yoon Jeong-Hyuk, Han Yong-Hyun
Laboratory of Pathology and Physiology, College of Pharmacy, Kangwon National University, 1, Kangwondaehak-gil, Chuncheon-si, Gangwon-do, 24341, South Korea.
Multidimentional Genomics Research Center, Kangwon National University, Chuncheon, 24341, South Korea.
Arch Pharm Res. 2025 Feb;48(2):132-149. doi: 10.1007/s12272-024-01529-7. Epub 2024 Dec 26.
Immunosenescence is a weakening of the immune system due to aging, characterized by changes in immune cells and dysregulated immune function. Age-related immune cells are increasing with aging. They are associated with chronic prolonged inflammation, causing tissue dysfunction and age-related diseases. Here, we discuss increased pro-inflammatory activity of aged macrophages, accumulation of lymphocytes with an age-associated phenotype, and specific alterations in both functions and characteristics of these immune cells. These cellular changes are associated with development of age-related diseases. Additionally, we reviewed various therapeutic strategies targeting age-related immunosenescence, providing pathways to mitigate effects of age-related diseases.
免疫衰老指免疫系统因衰老而减弱，其特征为免疫细胞变化和免疫功能失调。与年龄相关的免疫细胞随衰老而增加。它们与慢性长期炎症相关，导致组织功能障碍和与年龄相关的疾病。在此，我们讨论老年巨噬细胞促炎活性增加、具有年龄相关表型的淋巴细胞积累，以及这些免疫细胞在功能和特性方面的特定改变。这些细胞变化与年龄相关疾病的发生有关。此外，我们综述了针对与年龄相关的免疫衰老的各种治疗策略，提供了减轻与年龄相关疾病影响的途径。
