Lehman Paul A, Franz Thomas J
Department of Dermatology, University of Arkansas for Medical Sciences, John L. McCleelan Memorial Veterans Hospital, Little Rock, Ark., USA.
Skin Pharmacol Physiol. 2014;27(5):249-53. doi: 10.1159/000357478. Epub 2014 May 20.
A wide variety of cutaneous manifestations are associated with diabetes. However, there is a paucity of information on stratum corneum barrier function in diabetics, with and without insulin therapy.
To assess for alteration of the stratum corneum, its barrier function was tested by evaluating the percutaneous absorption of water, ethanol, lidocaine and hydrocortisone, in vitro, on normal control, 4-week diabetic and 8-day insulin-treated diabetic Sprague-Dawley CD rats.
Total water penetration was not different between the 3 groups though flux profiles were different. Both total penetration and peak flux of lidocaine and hydrocortisone increased slightly in the diabetic rats over the control group. However, total penetration and peak flux (including ethanol) were significantly increased in the insulin-treated rats.
The data indicate that diabetes modestly alters stratum corneum physiology but less so than that seen following insulin therapy.
糖尿病与多种皮肤表现相关。然而，关于接受和未接受胰岛素治疗的糖尿病患者角质层屏障功能的信息却很少。
为评估角质层的变化，通过体外评估正常对照、4周龄糖尿病和8天胰岛素治疗的糖尿病斯普拉格-道利CD大鼠对水、乙醇、利多卡因和氢化可的松的经皮吸收，来测试其屏障功能。
尽管通量曲线不同，但三组之间的总水渗透率并无差异。糖尿病大鼠中利多卡因和氢化可的松的总渗透率和峰值通量均比对照组略有增加。然而，胰岛素治疗组大鼠的总渗透率和峰值通量（包括乙醇）显著增加。
数据表明，糖尿病会适度改变角质层生理功能，但程度低于胰岛素治疗后的改变。
