人类成体干细胞作为肿瘤发生起始及“癌症干细胞”产生的靶细胞。
Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of "cancer stem cells".
作者信息
Trosko James E
机构信息
Department of Pediatrics/Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, USA.
出版信息
Int J Stem Cells. 2008 Nov;1(1):8-26. doi: 10.15283/ijsc.2008.1.1.8.
The inference to stem cells has been found in ancient myths and the concept of stem cells has existed in the fields of plant biology, developmental biology and embryology for decades. In the field of cancer research, the stem cell theory was one of the earliest hypotheses on the origin of a cancer from a single cell. However, an opposing hypothesis had it that an adult differentiated somatic cell could "de-differentiate" to become a cancer cell. Only within the last decade, via the "cloning" of Dolly, the sheep, did the field of stem cell biology really trigger an exciting revolution in biological research. The isolation of human embryonic stem cells has created a true revolution in the life sciences that has led to the hope that these human stem cells could lead to (a) basic science understanding of gene regulation during differentiation and development; (b) stem cell therapy; (c) gene therapy via stem cells; (d) the use of stem cells for drug discovery; (e) screening for toxic effects of chemicals; and (f) understand the aging and diseases of aging processes.
干细胞的推断在古代神话中就已出现，并且干细胞的概念在植物生物学、发育生物学和胚胎学领域已经存在了数十年。在癌症研究领域，干细胞理论是关于癌症起源于单个细胞的最早假说之一。然而，另一种相反的假说认为，成年分化体细胞可以“去分化”成为癌细胞。直到最近十年，通过克隆绵羊多莉，干细胞生物学领域才真正引发了生物学研究中的一场激动人心的革命。人类胚胎干细胞的分离在生命科学领域引发了一场真正的革命，带来了这样的希望：这些人类干细胞能够带来（a）对分化和发育过程中基因调控的基础科学理解；（b）干细胞治疗；（c）通过干细胞进行基因治疗；（d）利用干细胞进行药物发现；（e）筛选化学物质的毒性作用；以及（f）理解衰老和衰老过程中的疾病。
Zotero 插件