Carrasco Fernández J R, Gómez-Pastrana D, Alados Arboledas J C, Aragón Fernández C, Ortiz Tardío J
Servicio de Pediatría, Hospital General de Jerez de la Frontera, Cádiz, España.
Servicio de Pediatría, Hospital General de Jerez de la Frontera, Cádiz, España.
An Pediatr (Barc). 2015 Jan;82(1):e26-9. doi: 10.1016/j.anpedi.2014.04.011. Epub 2014 May 22.
The diagnosis of aseptic meningitis, based on an enterovirus PCR (EV-PCR) in cerebrospinal fluid, is a rapid and sensitive test.
To assess the impact of introducing EV-PCR on the use of antibiotics and hospital length of stay in aseptic meningitis.
A prospective study that included children with aseptic meningitis during one year. The patients prior to the introduction of the test formed the control group.
The performance of the PCR test was associated with less use of antibiotics compared to the control group (16.2% vs 41.4%, P=.029) and with fewer days of administration (.54 vs. 2 days, P=.014). A non-significant decrease in length of stay (3.57 vs. 4.21 days, P=.376) was also observed in the study group.
The introduction of the EV-PCR test decreases the use of antibiotics and hospital length of stay.
基于脑脊液肠道病毒聚合酶链反应（EV-PCR）诊断无菌性脑膜炎是一种快速且灵敏的检测方法。
评估引入EV-PCR对无菌性脑膜炎抗生素使用及住院时间的影响。
一项前瞻性研究，纳入了一年内患无菌性脑膜炎的儿童。在引入该检测方法之前的患者构成对照组。
与对照组相比，PCR检测的应用与抗生素使用减少相关（16.2%对41.4%，P = 0.029），且给药天数减少（0.54天对2天，P = 0.014）。研究组住院时间也有非显著性下降（3.57天对4.21天，P = 0.376）。
引入EV-PCR检测可减少抗生素使用及住院时间。
