Tähkä K M
Department of Zoology, University of Helsinki, Finland.
Int J Dev Biol. 1989 Mar;33(1):141-8.
The gonads are unique organs in that they harbor the cells of the germline and consequently provide the local environment necessary for the normal development and differentiation of gametes. Since the local requirements for germ differentiation differ considerably from those of somatic cells the structural and physiological organization of the gonad is complex and compartmentalized. An elaborate network of local paracrine interactions between the somatic and gametogenic elements appears to be essential for normal germ cell development in mammals. This is especially true for the testis where meiosis is continuous throughout adulthood and where the spermatogenic cycle of the seminiferous epithelium is strictly controlled in time and space. The present paper reviews briefly the rapidly expanding field of testicular paracrinology. Special emphasis is given to the role of intra- and intercompartmental paracrine communication in the development of the male gamete.
性腺是独特的器官，因为它们容纳生殖系细胞，从而为配子的正常发育和分化提供必要的局部环境。由于生殖细胞分化的局部需求与体细胞的需求有很大差异，性腺的结构和生理组织复杂且呈分隔状态。体细胞和生精细胞成分之间精心构建的局部旁分泌相互作用网络似乎对哺乳动物正常生殖细胞发育至关重要。这在睾丸中尤为如此，在睾丸中，减数分裂在成年期持续进行，生精上皮的生精周期在时间和空间上受到严格控制。本文简要综述了睾丸旁分泌学这一迅速发展的领域。特别强调了隔室内和隔室间旁分泌通讯在雄性配子发育中的作用。
