从腹内侧到背外侧纹状体：奖励引导决策的神经关联
From ventral-medial to dorsal-lateral striatum: neural correlates of reward-guided decision-making.
作者信息
Burton Amanda C, Nakamura Kae, Roesch Matthew R
机构信息
Department of Psychology, University of Maryland, College Park, MD 20742, United States; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD 20742, United States.
Department of Physiology, Kansai Medical University, Shin-machi, Hirakata City, Osaka 570-1010, Japan; Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan.
出版信息
Neurobiol Learn Mem. 2015 Jan;117:51-9. doi: 10.1016/j.nlm.2014.05.003. Epub 2014 May 21.
The striatum is critical for reward-guided and habitual behavior. Anatomical and interference studies suggest a functional heterogeneity within striatum. Medial regions, such as nucleus accumbens core and dorsal medial striatum play roles in goal-directed behavior, while dorsal lateral striatum is critical for control of habitual action. Subdivisions of striatum are topographically connected with different cortical and subcortical structures forming channels that carry information related to limbic, associative, and sensorimotor functions. Here, we describe data showing that as one progresses from ventral-medial to dorsal-lateral striatum, there is a shift from more prominent value encoding to activity more closely related to associative and motor aspects of decision-making. In addition, we will describe data suggesting that striatal circuits work in parallel to control behavior and that regions within striatum can compensate for each other when functions are disrupted.
纹状体对于奖赏引导和习惯性行为至关重要。解剖学和干预研究表明纹状体内存在功能异质性。内侧区域，如伏隔核核心和背内侧纹状体，在目标导向行为中发挥作用，而背外侧纹状体对于习惯性动作的控制至关重要。纹状体的细分区域与不同的皮质和皮质下结构存在拓扑连接，形成携带与边缘系统、联合和感觉运动功能相关信息的通道。在此，我们描述的数据表明，随着从腹内侧向背外侧纹状体的推进，存在从更突出的值编码向与决策的联合和运动方面更密切相关的活动的转变。此外，我们将描述的数据表明，纹状体回路并行工作以控制行为，并且当功能受到干扰时，纹状体内的区域可以相互补偿。
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