Kunishio K, Haber S N
Department of Neurobiology and Anatomy, University of Rochester of Medicine, New York 14642.
J Comp Neurol. 1994 Dec 15;350(3):337-56. doi: 10.1002/cne.903500302.
The organization of the projections from the cingulate cortex to the striatum in the monkey was studied using the retrograde tracers Lucifer Yellow conjugated to dextran amines and horseradish peroxidase conjugated to wheat germ agglutinin. These tracers were injected into the different regions of the ventral (limbic) striatum and the dorsal (sensorimotor) striatum. The shell region of the nucleus accumbens was defined using calbindin-D28K immunohistochemistry. Following injections into the ventral striatum, there are numerous retrogradely labeled neurons in the various regions of the primate cingulate cortex, most of which are derived from layer V. The cytoarchitectural subdivisions of cingulate cortex include the anterior cingulate cortex, areas 25, 24a-c, and 24a'-c', and the posterior cingulate cortex, areas 23a-c, 29, 30, and 31. There is a topographical organization of the projections from these different cingulate areas to the ventral and dorsal striatum. The medial ventral striatum receives input from the rostral part of the anterior cingulate cortex (areas 25 and 24a,b). The shell region of the nucleus accumbens receives fibers from areas 25, 24a,b, and 24a',b'. Projections to the central ventral striatum including the core of the nucleus accumbens are derived primarily from areas 25, 24a, 24b, and the medial part of area 24c. However, few labeled cells are detected in areas 24c and 24c'. The lateral ventral striatum receives input primarily from areas 24b, 24b' and 23b and medial portion of area 24c. The medial ventral striatum and the shell of the nucleus accumbens have a similar distribution of labeled cells, such that these regions derive their input almost entirely from the rostral anterior cingulate cortex. In contrast to the ventral striatum, the dorsal sensorimotor striatum receives projections from areas 24c, 24c' 23c and 31. These arise primarily from the lateral portion of lower bank and the fundus of the cingulate sulcus. Our results demonstrate that areas 24c, 24c' and 23c, the lateral portion of the lower bank and the fundus of the cingulate sulcus project to the dorsal sensorimotor striatum. The medial portion of the lower bank of the cingulate cortex projects to the ventral striatum including the core of the nucleus accumbens. Different projections to striatum from discrete subdivisions of cingulate cortex indicate that these areas are heterogeneous and have different functions such that the fundus of the cingulate sulcus is related to skeletomotor function, whereas the medial portion of the lower bank of the cingulate sulcus is associated with the limbic-related and association cortical function.(ABSTRACT TRUNCATED AT 400 WORDS)
利用与葡聚糖胺偶联的逆行示踪剂路西法黄和与麦胚凝集素偶联的辣根过氧化物酶，研究了猴子扣带回皮质到纹状体的投射组织。这些示踪剂被注射到腹侧（边缘）纹状体和背侧（感觉运动）纹状体的不同区域。伏隔核的壳区通过钙结合蛋白-D28K免疫组织化学来界定。向腹侧纹状体注射后，在灵长类扣带回皮质的各个区域有大量逆行标记的神经元，其中大多数来自第V层。扣带回皮质的细胞结构细分包括前扣带回皮质，即25区、24a - c区和24a' - c'区，以及后扣带回皮质，即23a - c区、29区、30区和31区。从这些不同的扣带回区域到腹侧和背侧纹状体的投射存在拓扑组织。内侧腹侧纹状体接受来自前扣带回皮质嘴侧部分（25区和24a、b区）的输入。伏隔核的壳区接受来自25区、24a、b区和24a'、b'区的纤维。向包括伏隔核核心在内的中央腹侧纹状体的投射主要来自25区、24a、24b区以及24c区的内侧部分。然而，在24c区和24c'区检测到的标记细胞很少。外侧腹侧纹状体主要接受来自24b、24b'区、23b区以及24c区内侧部分的输入。内侧腹侧纹状体和伏隔核的壳区有相似的标记细胞分布，使得这些区域的输入几乎完全来自嘴侧前扣带回皮质。与腹侧纹状体不同，背侧感觉运动纹状体接受来自24c、24c'区、23c区和31区的投射。这些投射主要来自扣带沟下岸外侧部分和沟底。我们的结果表明,24c、24c'区和23c区、扣带沟下岸外侧部分和沟底投射到背侧感觉运动纹状体。扣带回皮质下岸内侧部分投射到包括伏隔核核心在内的腹侧纹状体。扣带回皮质不同亚区向纹状体的不同投射表明这些区域是异质性的且具有不同功能，即扣带沟底与骨骼运动功能相关，而扣带沟下岸内侧部分与边缘相关及联合皮质功能相关。（摘要截选至400字）
