克鲁斯念珠菌血液分离株中通过fks1基因突变证实获得性棘白菌素耐药。
Acquired echinocandin resistance in a Candida krusei blood isolate confirmed by mutations in the fks1 gene.
作者信息
Prigitano Anna, Esposito Maria Carmela, Cogliati Massimo, Pitzurra Lucia, Santamaria Concetta, Tortorano Anna Maria
机构信息
Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Italy.
出版信息
New Microbiol. 2014 Apr;37(2):237-40. Epub 2014 Apr 1.
PMID:24858652
Abstract
We describe a case of bloodstream infection caused by a Candida krusei strain that developed echinocandin resistance during caspofungin therapy. Three mutations were found in the HS1 region of the fks1 gene, two of them have never been reported either in C. krusei nor in C. albicans.
摘要
我们描述了一例由克鲁斯念珠菌菌株引起的血流感染病例，该菌株在卡泊芬净治疗期间产生了棘白菌素耐药性。在fks1基因的HS1区域发现了三个突变，其中两个突变在克鲁斯念珠菌和白色念珠菌中均未见报道。
Zotero 插件