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克鲁斯念珠菌血液分离株中通过fks1基因突变证实获得性棘白菌素耐药。

Acquired echinocandin resistance in a Candida krusei blood isolate confirmed by mutations in the fks1 gene.

作者信息

Prigitano Anna, Esposito Maria Carmela, Cogliati Massimo, Pitzurra Lucia, Santamaria Concetta, Tortorano Anna Maria

机构信息

Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Italy.

出版信息

New Microbiol. 2014 Apr;37(2):237-40. Epub 2014 Apr 1.

PMID:24858652
Abstract

We describe a case of bloodstream infection caused by a Candida krusei strain that developed echinocandin resistance during caspofungin therapy. Three mutations were found in the HS1 region of the fks1 gene, two of them have never been reported either in C. krusei nor in C. albicans.

摘要

我们描述了一例由克鲁斯念珠菌菌株引起的血流感染病例，该菌株在卡泊芬净治疗期间产生了棘白菌素耐药性。在fks1基因的HS1区域发现了三个突变，其中两个突变在克鲁斯念珠菌和白色念珠菌中均未见报道。

相似文献

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Acquired echinocandin resistance in a Candida krusei blood isolate confirmed by mutations in the fks1 gene.克鲁斯念珠菌血液分离株中通过fks1基因突变证实获得性棘白菌素耐药。
New Microbiol. 2014 Apr;37(2):237-40. Epub 2014 Apr 1.
2
Presence of L701 M mutation in the FKS1 gene of echinocandin-susceptible Candida krusei isolates.对棘白菌素敏感的克鲁斯念珠菌分离株的FKS1基因中存在L701 M突变。
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Mutations in the fks1 gene in Candida albicans, C. tropicalis, and C. krusei correlate with elevated caspofungin MICs uncovered in AM3 medium using the method of the European Committee on Antibiotic Susceptibility Testing.白色念珠菌、热带念珠菌和克鲁斯念珠菌中fks1基因的突变，与采用欧洲抗生素敏感性试验委员会的方法在AM3培养基中发现的卡泊芬净最低抑菌浓度升高相关。
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Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase.一株克鲁斯假丝酵母因葡聚糖合酶修饰而获得棘白菌素耐药性。
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Echinocandin failure case due to a previously unreported FKS1 mutation in Candida krusei.克鲁斯念珠菌中一种先前未报道的FKS1突变导致棘白菌素治疗失败病例。
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