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热带念珠菌短期接触卡泊芬净进行经验性治疗后产生棘白菌素类耐药性的发展。

Development of Echinocandin Resistance in Candida tropicalis following Short-Term Exposure to Caspofungin for Empiric Therapy.

机构信息

Department of Microbiology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.

Mycology Reference Laboratory, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait.

出版信息

Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.01926-17. Print 2018 Apr.

DOI:10.1128/AAC.01926-17
PMID:29437623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5913946/
Abstract

Isolation of two echinocandin-resistant strains from endotracheal secretions of a patient following short-term exposure to caspofungin is described. Both strains exhibited resistance to echinocandins by Etest and reference broth microdilution, showing a homozygous S645P mutation within the hot spot 1 (HS-1) region of and belonging to a unique multilocus sequence type. Other isolates collected from patients in the same intensive care unit within a 60-day period were susceptible to echinocandins and contained wild-type sequences.

摘要

本文描述了一例患者在短期接触卡泊芬净后从气管分泌物中分离出两株棘白菌素耐药株。两株菌均通过 Etest 和参考肉汤微量稀释法对棘白菌素表现出耐药性，在 热点 1 (HS-1) 区域内存在 S645P 突变纯合子，属于独特的多位点序列型。在 60 天内同一重症监护病房中从其他患者中收集的其他 分离株对棘白菌素敏感，且包含野生型 序列。

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本文引用的文献

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A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance.一项针对印度 350 株假丝酵母菌（2009-17 年）抗真菌药敏模式的多中心研究：ERG11 和 FKS1 基因在唑类药物和棘白菌素类药物耐药中的作用。
J Antimicrob Chemother. 2018 Apr 1;73(4):891-899. doi: 10.1093/jac/dkx480.
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The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Murine Model of Candida glabrata Colonization and Systemic Dissemination.胃肠道是光滑念珠菌定植和全身播散的小鼠模型中棘白菌素类药物耐药的主要来源。
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01412-17. Print 2017 Dec.
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Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment.耐多药念珠菌：流行病学、分子机制与治疗。
J Infect Dis. 2017 Aug 15;216(suppl_3):S445-S451. doi: 10.1093/infdis/jix131.
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Population structure and molecular genetic characterization of clinical Candida tropicalis isolates from a tertiary-care hospital in Kuwait reveal infections with unique strains.科威特一家三级护理医院临床热带念珠菌分离株的种群结构和分子遗传学特征揭示了独特菌株的感染情况。
PLoS One. 2017 Aug 30;12(8):e0182292. doi: 10.1371/journal.pone.0182292. eCollection 2017.
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The global problem of antifungal resistance: prevalence, mechanisms, and management.全球抗真菌耐药性问题：流行率、机制和管理。
Lancet Infect Dis. 2017 Dec;17(12):e383-e392. doi: 10.1016/S1473-3099(17)30316-X. Epub 2017 Jul 31.
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Fruits as the vehicle of drug resistant pathogenic yeasts.水果作为耐药性病原性酵母菌的载体。
J Infect. 2017 Sep;75(3):254-262. doi: 10.1016/j.jinf.2017.06.005. Epub 2017 Jun 23.
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