Fernandez-Rodriguez E, Casanueva F F, Bernabeu I
Endocrinology Division, Servicio Gallego de Salud (SERGAS), Complejo Hospitalario Universitario de Santiago de Compostela, 15706, Santiago de Compostela, La Coruña, Spain.
Pituitary. 2015 Jun;18(3):431-40. doi: 10.1007/s11102-014-0574-9.
Certain clinical conditions and markers have recently been demonstrated to modify the natural history of acromegaly in affected patients. Thus, some clinical, histological, radiological and molecular factors are associated with more aggressive pituitary tumors that have higher biochemical activity, higher tumor volumes and decreased tumoral and biochemical responses to current therapies. However, these factors do not seem to have an equal influence on the prognosis of patients with acromegaly. We present a review of the factors that influence the clinical course of patients with acromegaly and propose a risk value for each factor that will allow prognostic scoring for affected patients by considering a combination of these factors.
最近已证实某些临床状况和标志物可改变肢端肥大症患者的自然病程。因此，一些临床、组织学、放射学和分子因素与侵袭性更强的垂体瘤相关，这些垂体瘤具有更高的生化活性、更大的肿瘤体积，并且对当前治疗的肿瘤和生化反应降低。然而，这些因素对肢端肥大症患者预后的影响似乎并不相同。我们综述了影响肢端肥大症患者临床病程的因素，并针对每个因素提出一个风险值，通过综合考虑这些因素，可为受影响患者进行预后评分。
