Australian Institute of Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia.
Pharmaceutics. 2014 May 22;6(2):235-48. doi: 10.3390/pharmaceutics6020235.
The synthesis method of layered double hydroxides (LDHs) determines nanoparticles' performance in biomedical applications. In this study, hydrothermal treatment as an important synthesis technique has been examined for its influence on the physicochemical properties and the drug release rate from drug-containing LDHs. We synthesised MgAl-LDHs intercalated with non-steroidal anti-inflammatory drugs (i.e., naproxen, diclofenac and ibuprofen) using a co-precipitation method with or without hydrothermal treatment (150 °C, 4 h). After being hydrothermally treated, LDH-drug crystallites increased in particle size and crystallinity, but did not change in the interlayer anion orientation, gallery height and chemical composition. The drug release patterns of all studied LDH-drug hybrids were biphasic and sustained. LDHs loaded with diclofenac had a quicker drug release rate compared with those with naproxen and ibuprofen, and the drug release from the hydrothermally-treated LDH-drug was slower than the freshly precipitated LDH-drug. These results suggest that the drug release of LDH-drugs is influenced by the crystallite size of LDHs, which can be controlled by hydrothermal treatment, as well as by the drug molecular physicochemical properties.
层状双氢氧化物（LDHs）的合成方法决定了纳米粒子在生物医学应用中的性能。在这项研究中，水热处理作为一种重要的合成技术，其对含药 LDHs 的物理化学性质和药物释放速率的影响已被研究。我们使用共沉淀法，在有或没有水热处理（150°C，4 小时）的情况下，合成了插层非甾体抗炎药物（如萘普生、双氯芬酸和布洛芬）的 MgAl-LDHs。经水热处理后，LDH-药物晶粒度增加，结晶度提高，但层间阴离子取向、层间距和化学成分没有变化。所有研究的 LDH-药物杂化物的药物释放模式均为两相和持续释放。与萘普生和布洛芬相比，负载双氯芬酸的 LDH 的药物释放速度更快，而经水热处理的 LDH-药物的药物释放速度比新沉淀的 LDH-药物慢。这些结果表明，LDH 药物的药物释放受 LDH 晶粒大小的影响，而晶粒大小可通过水热处理以及药物分子的物理化学性质来控制。
