Yousefi Vahid, Tarhriz Vahideh, Eyvazi Shirin, Dilmaghani Azita
Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Nanobiotechnology. 2020 Oct 29;18(1):155. doi: 10.1186/s12951-020-00718-y.
Magnetic nanocomposites with a core-shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier.
Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively.
The results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect.
The FeO@LDH-ibuprofen and FeO@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that FeO@LDH multicore-shell nanostructure may have potential application for constant drug delivery.
具有核壳纳米结构的磁性纳米复合材料由于其独特的物理和化学性质，在不同科学领域尤其是药物释放方面有巨大应用。本研究通过简便实验合成了磁性@层状双氢氧化物多核@壳纳米结构，并将其用作新型药物纳米载体。
通过简便的一步溶剂热法合成磁性纳米球，然后通过共沉淀实验在磁性纳米球上制备层状双氢氧化物纳米片。分别用傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、扫描电子显微镜（SEM）、振动样品磁强计（VSM）和透射电子显微镜（TEM）对合成的纳米结构进行表征。在用布洛芬和双氯芬酸作为抗炎药物进行插层并采用交换阴离子实验后，将合成的层状双氢氧化物的基面间距分别与水镁石纳米片的0.48纳米、2.62纳米和2.22纳米进行比较。
结果表明，布洛芬和双氯芬酸通过桥连双齿相互作用成功插层到层状双氢氧化物的层间空间。此外，在pH 7.4的磷酸盐缓冲盐水（PBS）中进行的体外药物释放实验显示，以具有不同亲脂性、水溶性、尺寸和空间效应的布洛芬和双氯芬酸为模型药物时呈现出恒速释放曲线。
FeO@LDH - 布洛芬和FeO@LDH - 双氯芬酸具有羧基与高价三价阳离子通过桥连双齿形成强相互作用、透明度高和热稳定性高的优点。证实了FeO@LDH多核壳纳米结构在恒速药物递送方面可能具有潜在应用。
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