中文传统医学与海马体中的成人神经发生。
Chinese traditional medicine and adult neurogenesis in the hippocampus.
机构信息
Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China. ; Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
School of Chinese Medicine, Research Center of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Hong Kong, China.
出版信息
J Tradit Complement Med. 2014 Apr;4(2):77-81. doi: 10.4103/2225-4110.130372.
Adult neurogenesis is an important therapeutic target in treating neurological disorders. Adult neurogenesis takes place in two regions of the brain: Subventricular zone and dentate gyrus in the hippocampus. The progressive understanding on hippocampal neurogenesis in aging and mood disorders increases the demand to explore powerful and subtle interventions on hippocampal neurogenesis. Traditional Chinese herbal medicine provides an abundant pharmaceutical platform for modulating hippocampal neurogenesis. Recent progress in exploring the effects of Chinese herbal medicine and the related mechanisms opens a new direction for regeneration therapy. The current review gives a thorough summary of the research progress made in traditional Chinese herbal formulas, and the effective compounds in Chinese herbs which are beneficial on hippocampal neurogenesis and the possible mechanisms involved.
成人神经发生是治疗神经退行性疾病的一个重要治疗靶点。成人神经发生发生在大脑的两个区域：脑室下区和海马齿状回。对衰老和情绪障碍中海马神经发生的逐渐深入的了解增加了对海马神经发生进行有力和微妙干预的需求。传统中药为调节海马神经发生提供了丰富的药物平台。最近在探索中药的作用及其相关机制方面取得的进展为再生治疗开辟了新的方向。本综述全面总结了传统中药方剂、中药中有利于海马神经发生的有效化合物及其可能涉及的机制方面的研究进展。
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