植物纳米材料作为治疗剂和药物递送载体。
Phytonanomaterials as therapeutic agents and drug delivery carriers.
作者信息
Xie Ying, Ma Chao, Yang Xin, Wang Jiacheng, Long Gretchen, Zhou Jiangbing
机构信息
Department of Neurosurgery, Yale University, New Haven, CT 06510, USA.
College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China.
出版信息
Adv Drug Deliv Rev. 2021 Sep;176:113868. doi: 10.1016/j.addr.2021.113868. Epub 2021 Jul 22.
Abstract
Medicinal plants have been a major resource for drug discovery. Emerging evidence shows that in addition to pharmacologically active components, medicinal plants also contain phytochemical nanomaterials, or phytonanomaterials, which form nanoparticles for drug delivery. In this review, we examine the evidence supporting the existence of phytonanomaterials. Next, we review identification, isolation, and classification of phytonanomaterials, characteristics of phytonanomaterial-derived nanoparticles, and molecular mechanisms of phytonanomaterial assembly. We will then summarize the current progress in exploring phytonanomaterial-derived NPs as therapeutic agents and drug delivery carriers for disease treatment. Last, we will provide perspectives on future discovery and applications of phytonanomaterials.
摘要
药用植物一直是药物发现的主要资源。新出现的证据表明，除了药理活性成分外，药用植物还含有植物化学纳米材料，即植物纳米材料，它们形成用于药物递送的纳米颗粒。在这篇综述中，我们研究了支持植物纳米材料存在的证据。接下来，我们回顾了植物纳米材料的鉴定、分离和分类，植物纳米材料衍生的纳米颗粒的特性，以及植物纳米材料组装的分子机制。然后，我们将总结在探索植物纳米材料衍生的纳米颗粒作为治疗疾病的治疗剂和药物递送载体方面的当前进展。最后，我们将对植物纳米材料的未来发现和应用提供展望。
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