Sahni Kanika, Gupta Vishal, Khanna Neena
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Indian Dermatol Online J. 2014 Apr;5(2):164-6. doi: 10.4103/2229-5178.131090.
Vitiligo is an acquired pigmentary disorder, clinically characterized by depigmented macules caused by destruction of melanocytes in the affected skin. Half of all patients develop the disease in childhood and adolescence before the age of 20 years, making vitiligo an important skin disease of childhood. There are numerous studies in the literature that suggest the efficacy of topical tacrolimus in vitiligo, without serious adverse effects. We describe a case of vitiligo in a pediatric patient who developed hyperpigmentation in the periorbital lesions of vitiligo with the use of topical tacrolimus. To the best of our knowledge, this is only the second such reported occurrence in a patient with vitiligo.
白癜风是一种获得性色素沉着障碍性疾病，临床特征为受累皮肤中黑素细胞破坏导致的色素脱失斑。所有患者中有一半在20岁之前的儿童期和青少年期发病，这使得白癜风成为一种重要的儿童皮肤病。文献中有大量研究表明外用他克莫司治疗白癜风有效，且无严重不良反应。我们描述了1例儿科白癜风患者，其在使用外用他克莫司后白癜风眶周皮损出现色素沉着。据我们所知，这是白癜风患者中此类报道的第二例。
