Pisanti F A, Lucadamo L, Aloj Totaro E
Stazione Zoologica, Napoli, Italy.
Adv Exp Med Biol. 1989;266:135-41; discussion 141-2. doi: 10.1007/978-1-4899-5339-1_10.
The effect of the exposure of Torpedo marmorata to a single dose of 400 cGy of ionizing radiation and doses of 200 cGy/week for 4 weeks has been studied. The parameters measured were the TBA reactivity and lipofuscin production, a fluorescent pigment that is thought to derive from the reaction of malonaldehyde, a peroxide-degradation product, with free amino-groups. Acute irradiation was found to generate an increase of peroxidative damage in some tissues. This effect was inhibited by acetyl homocysteine-thiolactone, a drug that increases the activity of tissue superoxide dismutase. Chronic irradiation produces a severe increase in the generation of lipofuscin.
已经研究了电鳐暴露于400 cGy的单次电离辐射剂量以及连续4周每周200 cGy剂量的影响。所测量的参数是硫代巴比妥酸反应性和脂褐素生成，脂褐素是一种荧光色素，被认为源自过氧化降解产物丙二醛与游离氨基的反应。发现急性辐射会导致某些组织中过氧化损伤增加。这种效应被乙酰高半胱氨酸硫内酯抑制，乙酰高半胱氨酸硫内酯是一种能提高组织超氧化物歧化酶活性的药物。慢性辐射会导致脂褐素生成大幅增加。
