从岩白菜中分离得到的11 - O - 没食子酰岩白菜素和岩白菜素的抗氧化及抗疟活性比较
Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata.
作者信息
Uddin G, Sadat A, Siddiqui B S
机构信息
Institute of Chemical Sciences, University of Peshawar, Peshawar, 25120, Pakistan.
HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
出版信息
Trop Biomed. 2014 Mar;31(1):143-8.
In the present study, the antioxidant and antiplasmodial activities of bergenin was compared with its natural derivative 11-O-galloylbergenin for the first time. Both compounds were isolated from Bergenia ligulata. 11-O-galloylbergenin was found to be very active in in-vitro antioxidant assay as compared to bergenin, which was found to be almost inactive. The EC50 values of 11-O-galloylbergenin were 7.45±0.2 μg/mL and 5.39±0.28 μg/mL in DPPH antioxidant assay and reducing power assay respectively, while IC50 value for antiplasmodial assay of both compounds were less than 2.5 μM. Interestingly, in the total antioxidant phosphomolybdate assay, 11-O-galloylbergenin was found more potent (CAHT: 940.04±115.30) as compared to α-tocopherol (CAHT: 552.4±27.91).
在本研究中，首次将岩白菜素与其天然衍生物11 - O - 没食子酰岩白菜素的抗氧化和抗疟活性进行了比较。这两种化合物均从岩白菜中分离得到。与几乎无活性的岩白菜素相比，发现11 - O - 没食子酰岩白菜素在体外抗氧化试验中具有很高的活性。在DPPH抗氧化试验和还原能力试验中，11 - O - 没食子酰岩白菜素的EC50值分别为7.45±0.2 μg/mL和5.39±0.28 μg/mL，而两种化合物的抗疟试验IC50值均小于2.5 μM。有趣的是，在总抗氧化磷钼酸盐试验中，发现11 - O - 没食子酰岩白菜素比α - 生育酚更有效（CAHT：940.04±115.30，α - 生育酚：CAHT：552.4±27.91）。
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