Bardají C, Martínez Bermejo M A, Conde J, de Prado M L, Bento L
Cir Pediatr. 1989 Jul;2(3):117-22.
Gastroesophageal reflux (GER) can be found in a high number of patients with respiratory tract disease (RTD). In the present study a 24 hours esophageal pH monitoring was performed in 55 children. 15 of them were normal controls, 16 patients with GER but normal score, 14 patients with GER and RTD and 9 patients with GER and only digestive symptoms. The number of reflux episodes of more than 5 minutes, the duration of the longest single reflux episode, the percentage of time the esophageal pH was less than 4, the reflux/hour index and the clearance index were measured. Comparing the results of the different groups we found that normal controls and normal vomiting patients were significatively different. Refluxers and refluxers with RTD also were different of asymptomatic controls. The main significative differences founded comparing refluxers and refluxers with RTD were the duration of the longest single reflux, the percentage of time the esophageal pH was less than 4 and the clearance index. All these parameters were longer in the refluxers with RTD. Our conclusion is that esophageal clearance is slower in the group of refluxers with RTD and that this index is helpful to distinguish them from the single refluxers.
胃食管反流(GER)在大量呼吸道疾病(RTD)患者中较为常见。在本研究中,对55名儿童进行了24小时食管pH监测。其中15名是正常对照组,16名有GER但评分正常,14名有GER和RTD,9名有GER且仅有消化系统症状。测量了反流持续超过5分钟的次数、最长单次反流持续时间、食管pH低于4的时间百分比、每小时反流指数和清除指数。比较不同组的结果,我们发现正常对照组和正常呕吐患者有显著差异。反流患者和伴有RTD的反流患者与无症状对照组也不同。比较反流患者和伴有RTD的反流患者发现的主要显著差异是最长单次反流持续时间、食管pH低于4的时间百分比和清除指数。所有这些参数在伴有RTD的反流患者中更长。我们的结论是,伴有RTD的反流患者组的食管清除较慢,并且该指数有助于将他们与单纯反流患者区分开来。