昼夜节律钟对内分泌因子的控制。
Circadian clock control of endocrine factors.
机构信息
Division of Behavioural Neurobiology, Department of Psychiatry, Department of Medicine, University of Alabama at Birmingham, 703 19th Street South, Birmingham, AL 35294, USA.
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Alabama at Birmingham, 703 19th Street South, Birmingham, AL 35294, USA.
出版信息
Nat Rev Endocrinol. 2014 Aug;10(8):466-75. doi: 10.1038/nrendo.2014.78. Epub 2014 May 27.
Organisms experience dramatic fluctuations in demands and stresses over the course of the day. In order to maintain biological processes within physiological boundaries, mechanisms have evolved for anticipation of, and adaptation to, these daily fluctuations. Endocrine factors have an integral role in homeostasis. Not only do circulating levels of various endocrine factors oscillate over the 24 h period, but so too does responsiveness of target tissues to these signals or stimuli. Emerging evidence suggests that these daily endocrine oscillations do not occur solely in response to behavioural fluctuations associated with sleep-wake and feeding-fasting cycles, but are orchestrated by an intrinsic timekeeping mechanism known as the circadian clock. Disruption of circadian clocks by genetic and/or environmental factors seems to precipitate numerous common disorders, including the metabolic syndrome and cancer. Collectively, these observations suggest that strategies designed to realign normal circadian rhythmicities hold potential for the treatment of various endocrine-related disorders.
生物体在一天的过程中经历着需求和压力的剧烈波动。为了使生物过程维持在生理范围内，生物体进化出了对这些日常波动的预期和适应机制。内分泌因素在体内平衡中起着不可或缺的作用。不仅各种内分泌因素的循环水平在 24 小时内波动，而且靶组织对这些信号或刺激的反应性也是如此。新出现的证据表明，这些日常的内分泌波动不仅是对与睡眠-觉醒和进食-禁食周期相关的行为波动的反应，而是由一种被称为生物钟的内在计时机制来协调的。遗传和/或环境因素对生物钟的破坏似乎会引发许多常见疾病，包括代谢综合征和癌症。总的来说，这些观察结果表明，旨在调整正常昼夜节律的策略可能为治疗各种与内分泌相关的疾病提供了潜力。
Zotero 插件