Albaqami Amirah
Department of Clinical Laboratory Sciences, Turabah University College, Taif University, Taif, Saudi Arabia.
Front Pharmacol. 2025 May 27;16:1617713. doi: 10.3389/fphar.2025.1617713. eCollection 2025.
The circadian clock is present in nearly all tissues (including glial cells), which play crucial roles in brain functions and development. Circadian clock genes (CCGs) are responsible for regulating numerous cancer-associated biological mechanisms, including the regulation of cell cycle genes, apoptosis, and cell proliferation. A range of studies have already confirmed the potential link between brain tumors and CCGs, including Growing evidence regarding gliomas including glioblastoma multiforme (GBM) indicates the significance of modulation of CCG in cancer biology. Various studies have already revealed how tumor cells can disrupt CCGs to safeguard their survival. It has also recently been demonstrated in the case of gliomas (especially GBM) that CCGs should be targeted for the development of novel therapies or to ameliorate the current treatments that impair and abolish tumor growth. Multiple pharmacological modulators have been reported as effective in regulating CCGs in brain tumors, such as temozolomide, inhibitors of casein kinase 1 and casein kinase 2, curcumin, norepinephrine, melatonin, REV-ERB agonists, agonists of the retinoic acid-related orphan receptor, cryptochrome protein stabilizers, and 1A-116. In this review, an overview of brain tumors, the genetics of circadian clock, and the link between pathological disruptions of the CCGs and brain tumor development have been discussed. In addition, potential pharmacological interventions to modulate CCGs in brain tumors have also been reviewed.
生物钟存在于几乎所有组织（包括神经胶质细胞）中，这些组织在大脑功能和发育中发挥着关键作用。生物钟基因负责调节众多与癌症相关的生物学机制，包括细胞周期基因的调节、细胞凋亡和细胞增殖。一系列研究已经证实了脑肿瘤与生物钟基因之间的潜在联系，包括 越来越多关于胶质瘤（包括多形性胶质母细胞瘤，GBM）的证据表明，调节生物钟基因在癌症生物学中具有重要意义。各种研究已经揭示了肿瘤细胞如何破坏生物钟基因以保障自身存活。最近在胶质瘤（尤其是GBM）的案例中也证明，生物钟基因应成为开发新疗法或改善当前损害和消除肿瘤生长的治疗方法的靶点。据报道，多种药理调节剂在调节脑肿瘤中的生物钟基因方面有效，如替莫唑胺、酪蛋白激酶1和酪蛋白激酶2抑制剂、姜黄素、去甲肾上腺素、褪黑素、REV-ERB激动剂、视黄酸相关孤儿受体激动剂、隐花色素蛋白稳定剂和1A-116。在这篇综述中，讨论了脑肿瘤的概述、生物钟的遗传学以及生物钟基因的病理破坏与脑肿瘤发展之间的联系。此外，还综述了调节脑肿瘤中生物钟基因的潜在药理干预措施。
