Catalá-López Ferrán, Fernández de Larrea-Baz Nerea, Morant-Ginestar Consuelo, Álvarez-Martín Elena, Díaz-Guzmán Jaime, Gènova-Maleras Ricard
Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines and Healthcare Products Agency (AEMPS), Madrid, Spain; Fundación Instituto de Investigación en Servicios de Salud, Valencia, Spain.
Health Research, Training and Infrastructures General Directorate, Regional Health Council, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Madrid, Spain.
Med Clin (Barc). 2015 Apr 20;144(8):353-9. doi: 10.1016/j.medcli.2013.11.040. Epub 2014 May 23.
The aim of the present study was to determine the national burden of cerebrovascular diseases in the adult population of Spain.
Cross-sectional, descriptive population-based study. We calculated the disability-adjusted life years (DALY) metric using country-specific data from national statistics and epidemiological studies to obtain representative outcomes for the Spanish population. DALYs were divided into years of life lost due to premature mortality (YLLs) and years of life lived with disability (YLDs). DALYs were estimated for the year 2008 by applying demographic structure by sex and age-groups, cause-specific mortality, morbidity data and new disability weights proposed in the recent Global Burden of Disease study. In the base case, neither YLLs nor YLDs were discounted or age-weighted. Uncertainty around DALYs was tested using sensitivity analyses.
In Spain, cerebrovascular diseases generated 418,052 DALYs, comprising 337,000 (80.6%) YLLs and 81,052 (19.4%) YLDs. This accounts for 1,113 DALYs per 100,000 population (men: 1,197 and women: 1,033) and 3,912 per 100,000 in those over the age of 65 years (men: 4,427 and women: 2,033). Depending on the standard life table and choice of social values used for calculation, total DALYs varied by 15.3% and 59.9% below the main estimate.
Estimates provided here represent a comprehensive analysis of the burden of cerebrovascular diseases at a national level. Prevention and control programmes aimed at reducing the disease burden merit further priority in Spain.
本研究旨在确定西班牙成年人群中脑血管疾病的全国负担。
基于人群的横断面描述性研究。我们使用来自国家统计数据和流行病学研究的特定国家数据计算伤残调整生命年（DALY）指标，以获得西班牙人群具有代表性的结果。DALY分为因过早死亡导致的生命年损失（YLL）和伴有残疾生存的生命年（YLD）。通过应用按性别和年龄组划分的人口结构、特定病因死亡率、发病率数据以及近期全球疾病负担研究中提出的新残疾权重，对2008年的DALY进行了估计。在基础病例中，YLL和YLD均未进行贴现或年龄加权。使用敏感性分析测试DALY周围的不确定性。
在西班牙，脑血管疾病产生了418,052个DALY，其中包括337,000个（80.6%）YLL和81,052个（19.4%）YLD。这相当于每10万人口中有1,113个DALY（男性：1,197个，女性：1,033个），65岁以上人群中每10万人口中有3,912个（男性：4,427个，女性：2,033个）。根据用于计算的标准生命表和社会价值选择，总DALY比主要估计值分别低15.3%和59.9%。
此处提供的估计值代表了对西班牙全国范围内脑血管疾病负担的全面分析。在西班牙，旨在减轻疾病负担的预防和控制计划应进一步优先考虑。
