Kim Hong-Bae, Lee Yong-Jae
Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Gyeonggi-do.
Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.
Medicine (Baltimore). 2020 Apr;99(14):e19529. doi: 10.1097/MD.0000000000019529.
Resting heart rate, a simple and useful indicator of autonomic function, and its imbalance has emerged as an independent predictor of cardio metabolic diseases. Nonalcoholic fatty liver disease (NAFLD) is increasingly being diagnosed worldwide and is strongly associated with the features of cardiometabolic diseases. This study aimed to examine the association between resting heart rate and NAFLD in postmenopausal women.The cross-sectional study included 1017 postmenopausal women aged ≥46 years, who attended a health examination program. Resting heart rate and NAFLD were measured in all subjects who underwent a medical examination. Resting heart rate quartiles were categorized as follows: Q1: 56 to 65, Q2: 66 to 71, Q3: 72 to 78, and Q4: 79 to 99 beats/min. The odds ratios and 95% confidence intervals for NAFLD were calculated after adjusting for confounding variables across resting heart rate quartiles using multiple logistic regression analysis.The prevalence of NAFLD increased with increasing resting heart rate quartiles: 28.2% for Q1, 31.5% for Q2, 33.4% for Q3, and 38.1% for Q4 (P < .001). Compared to the 1st quartile, the odds ratio (95% confidence intervals) of NAFLD in the 4th quartile of resting heart rates was 2.11 (1.17-3.42) after adjusting for age, body mass index, cigarette smoking, regular exercise, blood pressure, total cholesterol, triglyceride, aspartate aminotransferase, and alanine aminotransferase levels.Resting heart rate was positively associated with NAFLD in postmenopausal women, suggesting that it could be a useful additional measure to assess the risk for NAFLD in postmenopausal women.
静息心率是自主神经功能一个简单且有用的指标，其失衡已成为心脏代谢疾病的独立预测因子。非酒精性脂肪性肝病（NAFLD）在全球范围内的诊断率日益增加，且与心脏代谢疾病的特征密切相关。本研究旨在探讨绝经后女性静息心率与NAFLD之间的关联。
这项横断面研究纳入了1017名年龄≥46岁参加健康体检项目的绝经后女性。对所有接受体检的受试者测量静息心率和NAFLD。静息心率四分位数分类如下：Q1：56至65次/分钟，Q2：66至71次/分钟，Q3：72至78次/分钟，Q4：79至99次/分钟。使用多因素逻辑回归分析，在校正静息心率四分位数的混杂变量后，计算NAFLD的比值比和95%置信区间。
NAFLD的患病率随着静息心率四分位数的增加而升高：Q1为28.2%，Q2为31.5%，Q3为33.4%，Q4为38.1%（P<0.001）。在校正年龄、体重指数、吸烟、规律运动、血压、总胆固醇、甘油三酯、天冬氨酸转氨酶和丙氨酸转氨酶水平后，静息心率第四四分位数的NAFLD比值比（95%置信区间）与第一四分位数相比为2.11（1.17 - 3.42）。
绝经后女性静息心率与NAFLD呈正相关，表明它可能是评估绝经后女性NAFLD风险的一个有用的额外指标。
