Zhan Lei, Zhang Yan, Zeng Qiao Ling, Liu Zhong De, Huang Cheng Zhi
Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
J Colloid Interface Sci. 2014 Jul 15;426:293-9. doi: 10.1016/j.jcis.2014.03.056. Epub 2014 Apr 2.
A convenient and environment-friendly method is reported to synthesize the reduced graphene oxide (rGO) sheets in aqueous solution using folic acid (FA) as both a reducing and stabilizing agent, to improve the performance of graphene-based sensing strategy. The as-prepared FA-rGO sheets were characterized by transmission electron microscopy (TEM), UV-vis absorption spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, Raman spectroscopy, X-ray diffraction (XRD) and thermogravimetric analysis (TGA), which provided the clear identification of the removal of oxygen-containing functional groups from the graphene oxide (GO) to form FA-rGO sheets. Further, it was found that the obtained FA-rGO sheets exhibited better biocompatibility and could act as the more efficient energy acceptor in long range resonance energy transfer (LrRET) process than that of graphene. Additionally, the FA-rGO can also catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) by H2O2, and compared with GO sheets, they exhibited the more prominent intrinsic peroxidase-like activity, thus providing the more sensitive approach for colorimetric detection of H2O2.
据报道，一种便捷且环保的方法是在水溶液中使用叶酸（FA）作为还原和稳定剂来合成还原氧化石墨烯（rGO）片，以提高基于石墨烯的传感策略的性能。通过透射电子显微镜（TEM）、紫外可见吸收光谱、傅里叶变换红外（FT-IR）光谱、拉曼光谱、X射线衍射（XRD）和热重分析（TGA）对所制备的FA-rGO片进行了表征，这些表征明确证实了从氧化石墨烯（GO）中去除含氧官能团从而形成FA-rGO片。此外，发现所获得的FA-rGO片表现出更好的生物相容性，并且在长程共振能量转移（LrRET）过程中比石墨烯更能作为高效的能量受体。另外，FA-rGO还可以催化H2O2对3,3',5,5'-四甲基联苯胺（TMB）的氧化，并且与GO片相比，它们表现出更显著的内在过氧化物酶样活性，从而为H2O2的比色检测提供了更灵敏的方法。
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