Bush Sean P, Mooy Graham G, Phan Tammy H
Department of Emergency Medicine, Brody School of Medicine at East Carolina University, Greenville, NC.
Department of Emergency Medicine, Loma Linda University School of Medicine, Loma Linda, CA.
Wilderness Environ Med. 2014 Jun;25(2):198-203. doi: 10.1016/j.wem.2013.11.009.
We report 2 cases of catastrophic ischemic stroke after Crotalidae polyvalent immune Fab (ovine)-treated rattlesnake envenomation, 1 fatal and the other resulting in significant permanent disability. It is possible these serious adverse events may have been related to venom factor(s), an interaction between venom and antivenom, occult patient blood dyscrasia, or to random unrelated events. We present the rationale for each possibility, and submit the experiences to elicit alternate postulation and communication of similar presentations.
我们报告了2例经多价抗响尾蛇毒免疫Fab（羊源）治疗的响尾蛇咬伤后发生灾难性缺血性中风的病例，1例死亡，另1例导致严重永久性残疾。这些严重不良事件可能与毒液因子、毒液与抗蛇毒血清之间的相互作用、隐匿性患者血液恶液质或随机无关事件有关。我们阐述了每种可能性的依据，并分享这些经验以引发其他推测及交流类似病例。
