Spry N A, Lamb D S, Vaughan Hudson G, Easterling M J, MacLennan K A, Jelliffe A M
Department of Oncology, University College and Middlesex School of Medicine, London, UK.
Clin Oncol (R Coll Radiol). 1989 Sep;1(1):33-8. doi: 10.1016/s0936-6555(89)80009-3.
Eighty-eight patients entered into the British National Lymphoma Investigation with clinical stage I and II, grade I non-Hodgkin's lymphoma were treated initially with involved field radiotherapy alone. Eighty-one per cent presented with nodal disease. The duration of follow-up was 25-116 months, with a median of 54 months. Fifteen patients died of disease and the 5-year survival of the whole group was 83%. The complete response rate was dependent on the radiotherapy dose and was greater than 90% for doses of 3500 cGy and over. Most failures occurred at distant rather than adjacent sites, suggesting that extended field radiotherapy would not have affected the outcome. Second-line treatment induced complete remission in 66% of patients who relapsed. The prognosis was significantly worse in patients with intra-abdominal disease.
88例临床分期为I期和II期、I级非霍奇金淋巴瘤患者进入英国国家淋巴瘤研究，最初仅接受受累野放疗。81%的患者出现淋巴结疾病。随访时间为25 - 116个月，中位时间为54个月。15例患者死于疾病，全组5年生存率为83%。完全缓解率取决于放疗剂量，3500 cGy及以上剂量时完全缓解率大于90%。大多数复发发生在远处而非相邻部位，这表明扩大野放疗不会影响治疗结果。二线治疗使66%复发患者获得完全缓解。腹内疾病患者的预后明显更差。
