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台湾女性主要癌症的地理空间差异及其潜在原因。

Geospatial disparities and the underlying causes of major cancers for women in Taiwan.

作者信息

Chiang Chi-Ting, Lian Ie-Bin, Chang Ying-Fang, Chang Tsun-Kuo

机构信息

Green Energy and Environment Research Laboratories, Industrial Technology Research Institute, No. 195, Section 4, Chung Hsing Road, Chutung, Hsinchu 310, Taiwan.

Graduate Institute of Statistics and Information Science, National Changhua University of Education, No. 1, Jin-De Road, Changhua 500, Taiwan.

出版信息

Int J Environ Res Public Health. 2014 May 26;11(6):5613-27. doi: 10.3390/ijerph110605613.

DOI:10.3390/ijerph110605613
PMID:24865397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4078537/
Abstract

Some specific types of cancer still pose a severe threat to the health of Taiwanese women. This study focuses on determining the geographical locations of hot spots and causal factors related to the major categories of cancers in Taiwanese women. Cancer mortality data from 1972 to 2001 of 346 townships in Taiwan were obtained from the Atlas of Cancer Mortality. Principal component analysis was conducted to determine the primary categories of female cancers. The spatial patterns of hot spots and cold spots for each major cancer category were identified using the local indicator of spatial association. Finally, the regional differences between the hot spots and cold spots were compared to confirm the possible factors causing cancer throughout Taiwan. A total of 21 cancer types in women were divided into seven major categories, which accounted for 68.0% of the total variance. The results from the spatial autocorrelation analysis showed significant spatial clusters of the cancer categories. Based on the overall consistency of results between this study and those of previous research, this study further identified the high-risk locations and some specific risk factors for major cancer types among Taiwanese women.

摘要

某些特定类型的癌症仍然对台湾女性的健康构成严重威胁。本研究着重于确定台湾女性主要癌症类型的高发地区地理位置及相关致病因素。台湾346个乡镇1972年至2001年的癌症死亡率数据取自《癌症死亡率地图集》。进行主成分分析以确定女性癌症的主要类型。使用空间关联局部指标识别每种主要癌症类型的热点和冷点空间模式。最后,比较热点和冷点之间的区域差异,以确定全台湾可能导致癌症的因素。女性的21种癌症类型共分为七大类,占总方差的68.0%。空间自相关分析结果显示癌症类别存在显著的空间聚集。基于本研究与以往研究结果的总体一致性,本研究进一步确定了台湾女性主要癌症类型的高危地区及一些特定风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad2a/4078537/55c12f2a6f11/ijerph-11-05613-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad2a/4078537/71e8e1f64f7c/ijerph-11-05613-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad2a/4078537/55c12f2a6f11/ijerph-11-05613-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad2a/4078537/71e8e1f64f7c/ijerph-11-05613-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad2a/4078537/55c12f2a6f11/ijerph-11-05613-g002.jpg

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Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway.饮用水中的砷和铬会促进小鼠结肠炎相关结直肠癌模型中的肿瘤发生,其潜在机制是 ROS 介导的 Wnt/β-连环蛋白信号通路。
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Elucidating the underlying causes of oral cancer through spatial clustering in high-risk areas of Taiwan with a distinct gender ratio of incidence.通过台湾高风险地区的空间聚类分析,在发病率存在明显性别差异的情况下阐明口腔癌的潜在病因。
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Aetiology of cancer in Asia.亚洲癌症的病因
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SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan.台湾西南部谷胱甘肽S-转移酶M1、T1、P1、环氧化物水解酶及DNA修复酶XRCC1的单核苷酸多态性与尿路上皮细胞癌风险
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