Weiss Lindsay M, Petry Nancy M
University of Connecticut School of Medicine.
University of Connecticut School of Medicine.
J Subst Abuse Treat. 2014 Aug;47(2):146-50. doi: 10.1016/j.jsat.2014.04.003. Epub 2014 May 2.
Early onset drug use is associated with increased risk of developing substance use disorders, but relatively little is known about the correlates of early drug use among adults receiving treatment. A retrospective analysis of a randomized study of contingency management treatment compared cocaine-dependent patients who reported initial cocaine use at age 14 or younger (n = 41) to those who began using after age 14 (n = 387). Patients with early onset cocaine use had more legal and psychiatric problems than those who initiated cocaine use later. Patients with early-onset cocaine use also dropped out of treatment sooner and achieved less sustained abstinence than those who began using at older ages, but the interaction between age of first use and treatment condition was not significant. Early-onset cocaine use is associated with persistent psychosocial problems and an overall poor response to treatment. However, contingency management is efficacious in improving outcomes in early onset cocaine users.
早期药物使用与发展成物质使用障碍的风险增加有关，但对于接受治疗的成年人中早期药物使用的相关因素了解相对较少。一项对应急管理治疗随机研究的回顾性分析，将报告在14岁及以下首次使用可卡因的可卡因依赖患者（n = 41）与14岁以后开始使用可卡因的患者（n = 387）进行了比较。早期开始使用可卡因的患者比后来开始使用可卡因的患者有更多的法律和精神问题。与在较大年龄开始使用可卡因的患者相比，早期开始使用可卡因的患者也更早退出治疗，且维持戒断的时间更短，但首次使用年龄与治疗条件之间的相互作用并不显著。早期开始使用可卡因与持续的心理社会问题以及对治疗的总体不良反应有关。然而，应急管理在改善早期开始使用可卡因的使用者的治疗效果方面是有效的。
