Song Qingxu, Wang Jianbo, Jia Yibin, Wang Chuan, Wang Nana, Tan Bingxu, Ma Wei, Guan Shanghui, Jiang Dong, Cheng Yufeng
Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Ann Surg Oncol. 2014 Aug;21(8):2615-9. doi: 10.1245/s10434-014-3628-3. Epub 2014 May 28.
Gastric cancer remains the second cause of cancer-related death worldwide. The aim of this study was to investigate the effects of shorter dinner-to-bed time, post-dinner walk, and obesity on gastric cardia adenocarcinoma (GCA) risk.
The study subjects consisted of 146 GCA patients and 166 healthy controls roughly matched by gender and age. Conditional logistic regression was used to calculated odds ratio (OR) and 95 % confidence intervals (CIs).
The adjusted ORs of GCA for subjects with shorter dinner-to-bed time were 4.18 (95 % CI 2.10-8.33) compared with those with longer dinner-to-bed time. What is more, when reflux symptom was added into the multivariate models, risk estimate for shorter dinner-to-bed time decreased greatly, but still remained statistically significant (p = 0.007). Post-dinner walk was associated with a significantly decreased GCA risk (adjusted OR 0.54; 95 % CI 0.31-0.94). When subjects were analyzed according to post-dinner walk, the adjusted OR of GCA for shorter dinner-to-bed time relative to longer dinner-to-bed time was much higher for non-walking subjects (adjusted OR 20.21) than walking subjects (adjusted OR 1.39). We further found a significant interaction between shorter dinner-to-bed time and post-dinner walk regarding the risk of GCA (adjusted OR 0.07; p = 0.001).
We found that shorter dinner-to-bed time was associated with significantly increased GCA risk, partly depending on reflux symptoms, while post-dinner walk was related to a significantly decreased GCA risk and could greatly attenuate the GCA risk attributable to shorter dinner-to-bed time.
胃癌仍是全球癌症相关死亡的第二大原因。本研究旨在探讨晚餐至就寝时间缩短、晚餐后散步和肥胖对贲门腺癌（GCA）风险的影响。
研究对象包括146例GCA患者和166例年龄和性别大致匹配的健康对照。采用条件逻辑回归计算比值比（OR）和95%置信区间（CI）。
晚餐至就寝时间较短的受试者患GCA的调整后OR为4.18（95%CI 2.10 - 8.33），而晚餐至就寝时间较长的受试者。此外，当将反流症状纳入多变量模型时，晚餐至就寝时间较短的风险估计值大幅下降，但仍具有统计学意义（p = 0.007）。晚餐后散步与GCA风险显著降低相关（调整后OR 0.54；95%CI 0.31 - 0.94）。根据晚餐后散步情况分析受试者时，非散步受试者晚餐至就寝时间较短相对于较长时患GCA的调整后OR（调整后OR 20.21）远高于散步受试者（调整后OR 1.39）。我们进一步发现晚餐至就寝时间较短与晚餐后散步在GCA风险方面存在显著交互作用（调整后OR 0.07；p = 0.001）。
我们发现晚餐至就寝时间较短与GCA风险显著增加相关，部分取决于反流症状，而晚餐后散步与GCA风险显著降低相关，并且可以大大减轻因晚餐至就寝时间较短导致的GCA风险。
