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晚餐至就寝时间、晚餐后散步及睡眠时间与结直肠癌的关联:一项病例对照研究。

Associations of dinner-to-bed time, post-dinner walk and sleep duration with colorectal cancer: A case-control study.

作者信息

Lin Yanjuan, Peng Yanchun, Liang Bing, Zhu Shenshan, Li Lin, Jang Fei, Huang Xizhen, Xie Yuhong

机构信息

Department of Nursing Department of Colorectal surgery, Fujian Medical University Union Hospital, Fujian Province, China.

出版信息

Medicine (Baltimore). 2018 Aug;97(34):e12038. doi: 10.1097/MD.0000000000012038.

DOI:10.1097/MD.0000000000012038
PMID:30142855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6112920/
Abstract

Colorectal cancer (CRC) ranked 3rd for cancer incidence and 4th for cancer death worldwide. Despite the increasing number of CRC studies, the etiology is not yet clear. In this study, we investigated the effects of the dinner-to-bed time, post-dinner walk and sleep duration on the risk for CRC.We conducted a matched case-control study based on hospital population. We involved 166 patients had a newly histologically confirmed CRC without previous treatment and 166 healthy healthy residents matched by age and gender at Fujian Medical Union Hospital. A self-designed questionnaire was used to information on demographic characteristics, dinner-to-bed time, post-dinner walk, sleep duration, and other behavioral factors. Conditional logistic regression was used to calculate the odds ratio (OR) and 95% confidence intervals (95% CIs) to assess the effect of dinner-to-bed time, post-dinner walking, and sleep duration as well as their joint effect on the risk of CRC at different genders.The adjusted odds ratio (AOR) of CRC for subjects with shorter dinner-to-bed time (2.0-2.9 h) were 2.527 (95% CIs = 1.127-5.337), relative to those with longer dinner-to-bed time (≥4 h), the difference was statistically significant (P < .05). Post-dinner walk was associated with a significantly decreased CRC risk (AOR = 0.339, 95% CIs = 0.203-0.865) compared with post-dinner non-walk. Compared with 6-9 h of sleep duration, the risk OR of CRC were 3.843 (95% CIs = 2.767-7.800, P < .05) and 2.12 (95% CIs = 0.754-5.959, P > .05) for long (≥9 h) and short (<6 h) sleep duration. The risk of CRC individuals with shorter dinner-to-bed time and post-dinner non-walk caused higher risk than those with longer dinner-to-bed time and post-dinner walk (AOR = 3.361, 95% CIs = 2.043-6.316). The risk of CRC was 2.231 (95% CIs = 1.089-3.762, P < .001), with a shorter dinner-to-bed time and ≥9 hours of sleep duration.We found that shorter dinner-to-bed time (<3 h), post-dinner walk, and long sleep duration (≥9 h) were seems to be related to CRC and may increase the risk of CRC.

摘要

结直肠癌(CRC)在全球癌症发病率中排名第三,在癌症死亡率中排名第四。尽管CRC研究的数量不断增加,但其病因仍不清楚。在本研究中,我们调查了晚餐至就寝时间、晚餐后散步和睡眠时间对CRC风险的影响。我们基于医院人群进行了一项匹配病例对照研究。我们纳入了166例新组织学确诊且未经治疗的CRC患者,以及福建医科大学附属协和医院166名年龄和性别匹配的健康居民。使用自行设计的问卷收集人口统计学特征、晚餐至就寝时间、晚餐后散步、睡眠时间和其他行为因素的信息。采用条件逻辑回归计算比值比(OR)和95%置信区间(95%CI),以评估晚餐至就寝时间、晚餐后散步和睡眠时间及其联合作用对不同性别人群CRC风险的影响。晚餐至就寝时间较短(2.0 - 2.9小时)的受试者患CRC的调整后比值比(AOR)为2.527(95%CI = 1.127 - 5.337),相对于晚餐至就寝时间较长(≥4小时)的受试者,差异具有统计学意义(P < 0.05)。与晚餐后不散步相比,晚餐后散步与CRC风险显著降低相关(AOR = 0.339,95%CI = 0.203 - 0.865)。与睡眠时间为6 - 9小时相比,睡眠时间长(≥9小时)和短(<6小时)的CRC风险OR分别为3.843(95%CI = 2.767 - 7.800,P < 0.05)和2.12(95%CI = 0.754 - 5.959,P > 0.05)。晚餐至就寝时间较短且晚餐后不散步的个体患CRC的风险高于晚餐至就寝时间较长且晚餐后散步的个体(AOR = 3.361,95%CI = 2.043 - 6.316)。晚餐至就寝时间较短且睡眠时间≥9小时的个体患CRC的风险为2.231(95%CI = 1.089 - 3.762,P < 0.001)。我们发现晚餐至就寝时间较短(<3小时)、晚餐后散步和睡眠时间长(≥9小时)似乎与CRC有关,可能会增加患CRC的风险。

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