School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640 (P. R. China).
Angew Chem Int Ed Engl. 2014 Jul 7;53(28):7219-22. doi: 10.1002/anie.201403341. Epub 2014 May 27.
A highly efficient and mild palladium-catalyzed, one-pot, four-step cascade annulation has been developed to afford functionalized β- and γ-lactones in moderate to good yields with high regio- and diastereoselectivities in ionic liquids. The employment of ionic liquids under mild reaction conditions makes this transformation green and practical. Especially, this reaction provided a novel and convenient methodology for the construction of naturally occurring biologically active β- and γ-lactones.
发展了一种高效、温和的钯催化的一锅四步级联环化反应，在离子液体中以中等到良好的收率、高区域和非对映选择性得到官能化的β-和γ-内酯。在温和的反应条件下使用离子液体使这种转化具有绿色和实用的特点。特别是，该反应为构建天然存在的具有生物活性的β-和γ-内酯提供了一种新颖、方便的方法。
