新型三唑类抗真菌药艾氟康唑对皮肤癣菌获得性耐药的体外和体内评估
In vitro and in vivo assessment of dermatophyte acquired resistance to efinaconazole, a novel triazole antifungal.
作者信息
Iwata Atsushi, Watanabe Yoko, Kumagai Naomichi, Katafuchi-Nagashima Maria, Sugiura Keita, Pillai Radhakrishnan, Tatsumi Yoshiyuki
机构信息
Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan
Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan.
出版信息
Antimicrob Agents Chemother. 2014 Aug;58(8):4920-2. doi: 10.1128/AAC.02703-13. Epub 2014 May 27.
Abstract
Efinaconazole is a novel triazole antifungal drug for the topical treatment of onychomycosis, a nail infection caused mainly by dermatophytes. We assessed the potential of efinaconazole to induce resistance in dermatophytes by continuous exposure of Trichophyton rubrum strains to efinaconazole in vitro (12 passages) and in a guinea pig onychomycosis model (8 weeks). There was no evidence of efinaconazole resistance development in the tested strains under the experimental conditions used.
摘要
艾氟康唑是一种新型三唑类抗真菌药物，用于局部治疗甲癣，甲癣是一种主要由皮肤癣菌引起的指甲感染。我们通过在体外（12代）和豚鼠甲癣模型（8周）中将红色毛癣菌菌株持续暴露于艾氟康唑，评估了艾氟康唑诱导皮肤癣菌产生耐药性的可能性。在所使用的实验条件下，受试菌株没有出现艾氟康唑耐药性发展的迹象。
相似文献
1
In vitro and in vivo assessment of dermatophyte acquired resistance to efinaconazole, a novel triazole antifungal.新型三唑类抗真菌药艾氟康唑对皮肤癣菌获得性耐药的体外和体内评估
Antimicrob Agents Chemother. 2014 Aug;58(8):4920-2. doi: 10.1128/AAC.02703-13. Epub 2014 May 27.
2
Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis.比较依氟康唑与目前可用的抗真菌药物对各种与甲真菌病相关的致病性真菌的体外抗真菌活性。
Antimicrob Agents Chemother. 2013 Apr;57(4):1610-6. doi: 10.1128/AAC.02056-12. Epub 2013 Jan 14.
3
Ciclopirox and Efinaconazole Transungual Permeation, Antifungal Activity, and Proficiency To Induce Resistance in Trichophyton rubrum.环吡酮胺和依氟康唑经皮渗透、抗真菌活性及诱导红色毛癣菌耐药的能力。
Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.00442-19. Print 2019 Oct.
4
The low keratin affinity of efinaconazole contributes to its nail penetration and fungicidal activity in topical onychomycosis treatment.艾氟康唑对角蛋白的低亲和力有助于其在局部甲真菌病治疗中的指甲穿透性和杀菌活性。
Antimicrob Agents Chemother. 2014 Jul;58(7):3837-42. doi: 10.1128/AAC.00111-14. Epub 2014 Apr 21.
5
Evaluation of drug susceptibility test for Efinaconazole compared with conventional antifungal agents.棘白菌素类药物敏感性试验与传统抗真菌药物的比较评估。
Mycoses. 2019 Mar;62(3):291-297. doi: 10.1111/myc.12870. Epub 2018 Dec 17.
6
7
A comparative study between two antifungal agents, Luliconazole and Efinaconazole, of their preventive effects in a Trichophyton-infected guinea pig onychomycosis model.两种抗真菌药物（卢立康唑和依氟康唑）在预防豚鼠感染毛癣菌所致甲真菌病模型中的效果比较研究。
Med Mycol. 2021 Mar 4;59(3):289-295. doi: 10.1093/mmy/myaa111.
8
[Comparison of Characteristics of Two Topical Therapeutic Agents for Onychomycosis].[两种甲癣局部治疗药物的特性比较]
Med Mycol J. 2016;57(4):J141-J147. doi: 10.3314/mmj.16-00020.
9
Characteristics and Efficacy of Two Topical Therapeutic Agents for Onychomycosis.两种甲癣局部治疗药物的特性与疗效
Med Mycol J. 2019;60(3):71-74. doi: 10.3314/mmj.19.006.
10
Preparation and evaluation of a highly skin- and nail-permeable efinaconazole topical formulation for enhanced treatment of onychomycosis.制备并评价一种高透皮和透甲的依非康唑局部用制剂，以增强治疗甲真菌病的效果。
Drug Deliv. 2019 Dec;26(1):1167-1177. doi: 10.1080/10717544.2019.1687612.
引用本文的文献
1
Topical efinaconazole: A sequential combination therapy with oral terbinafine for refractory tinea unguium.局部用依氟康唑：口服特比萘芬序贯联合治疗难治性甲真菌病。
J Dermatol. 2021 Sep;48(9):1401-1404. doi: 10.1111/1346-8138.15973. Epub 2021 May 24.
2
Ciclopirox and Efinaconazole Transungual Permeation, Antifungal Activity, and Proficiency To Induce Resistance in Trichophyton rubrum.环吡酮胺和依氟康唑经皮渗透、抗真菌活性及诱导红色毛癣菌耐药的能力。
Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.00442-19. Print 2019 Oct.
3
Antifungal Activity of Novel Triazole Efinaconazole and Five Comparators against Dermatophyte Isolates.新型三唑类药物依氟康唑和五种对照药物对皮肤癣菌分离株的抗真菌活性。
Antimicrob Agents Chemother. 2018 Apr 26;62(5). doi: 10.1128/AAC.02423-17. Print 2018 May.
4
An Assessment of In Vitro Antifungal Activities of Efinaconazole and Itraconazole against Common Non-Dermatophyte Fungi Causing Onychomycosis.艾氟康唑和伊曲康唑对引起甲癣的常见非皮肤癣菌的体外抗真菌活性评估
J Fungi (Basel). 2017 May 5;3(2):20. doi: 10.3390/jof3020020.
5
Relevant Animal Models in Dermatophyte Research.相关的皮肤癣菌研究动物模型。
Mycopathologia. 2017 Feb;182(1-2):229-240. doi: 10.1007/s11046-016-0079-3. Epub 2016 Oct 11.
6
Efinaconazole in the treatment of onychomycosis.艾氟康唑治疗甲癣
Infect Drug Resist. 2015 Jun 1;8:163-72. doi: 10.2147/IDR.S69596. eCollection 2015.
本文引用的文献
1
In vitro antifungal activity of naftifine hydrochloride against dermatophytes.盐酸萘替芬对皮肤癣菌的体外抗真菌活性。
Antimicrob Agents Chemother. 2013 Sep;57(9):4369-72. doi: 10.1128/AAC.01084-13. Epub 2013 Jul 1.
2
Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis.比较依氟康唑与目前可用的抗真菌药物对各种与甲真菌病相关的致病性真菌的体外抗真菌活性。
Antimicrob Agents Chemother. 2013 Apr;57(4):1610-6. doi: 10.1128/AAC.02056-12. Epub 2013 Jan 14.
3
Efinaconazole 10% solution in the treatment of toenail onychomycosis: Two phase III multicenter, randomized, double-blind studies.依氟康唑 10% 溶液治疗趾甲甲真菌病：两项 III 期多中心、随机、双盲研究。
J Am Acad Dermatol. 2013 Apr;68(4):600-608. doi: 10.1016/j.jaad.2012.10.013. Epub 2012 Nov 20.
4
Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment.抗真菌药物耐药性：机制、流行病学及对治疗的影响。
Am J Med. 2012 Jan;125(1 Suppl):S3-13. doi: 10.1016/j.amjmed.2011.11.001.
5
Topical delivery of antifungal agents.局部用抗真菌药。
Expert Opin Drug Deliv. 2010 Nov;7(11):1303-27. doi: 10.1517/17425247.2010.525230. Epub 2010 Oct 20.
6
Toenail onychomycosis: an important global disease burden.甲真菌病：一种重要的全球性疾病负担。
J Clin Pharm Ther. 2010 Oct;35(5):497-519. doi: 10.1111/j.1365-2710.2009.01107.x.
7
Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure.烟曲霉中唑类耐药与治疗失败相关的频率及演变
Emerg Infect Dis. 2009 Jul;15(7):1068-76. doi: 10.3201/eid1507.090043.
8
Transcriptional profiles of Trichophyton rubrum in response to itraconazole.红色毛癣菌对伊曲康唑反应的转录谱
Med Mycol. 2009 May;47(3):237-47. doi: 10.1080/13693780802227308. Epub 2008 Jul 28.
9
In vitro antifungal drug susceptibilities of dermatophytes microconidia and arthroconidia.皮肤癣菌小分生孢子和关节孢子的体外抗真菌药敏性
J Antimicrob Chemother. 2008 Oct;62(4):758-61. doi: 10.1093/jac/dkn245. Epub 2008 Jun 13.
10
Evaluation of in vitro resistance in patients with onychomycosis who fail antifungal therapy.对抗真菌治疗失败的甲癣患者进行体外耐药性评估。
Dermatology. 2003;207(4):375-80. doi: 10.1159/000074118.
Zotero 插件