Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Department of Diagnostic Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
J Mov Disord. 2011 Oct;4(2):60-3. doi: 10.14802/jmd.11012. Epub 2011 Oct 30.
Susceptibility-weighted imaging (SWI) has been shown to be superior in its ability to demonstrate brain mineralization than other conventional MR imaging. The goal of our study was therefore to assess the frequency and extent of putaminal hypointensity in parkinsonian variant MSA using SWI.
11 patients with multiple system atrophy-parkinsonian type (MSA-p), 30 patients with Parkinson's disease (PD), and age matched 30 controls were investigated using 3 Tesla MRI. The pattern of putaminal hypointensity was measured using a visual grading scale and scored from 0 to 3.
Hemi- or bilateral putaminal hypointensity (a score of ≥ 2) and hyperintense rim were recognized in 81.8% and 54.5% of 11 MSA-p, respectively. The scores of putaminal hypointensity of MSA-p were significantly higher than other groups (p < 0.001), a score of ≥ 2 differentiated MSA-p from other groups. And all five patients with early disease stage also showed these characteristic findings.
SWI appears to be useful for depicting putaminal hypointensity even in early stage of MSA-p. This finding suggests that iron deposition associated putaminal degeneration can occur early in the disease process.
磁共振磁敏感加权成像（SWI）在显示脑矿化方面优于其他常规磁共振成像。因此，我们的研究目的是使用 SWI 评估帕金森变异型多系统萎缩（MSA-p）患者壳核低信号的频率和程度。
使用 3.0T MRI 对 11 例多系统萎缩-帕金森型（MSA-p）患者、30 例帕金森病（PD）患者和年龄匹配的 30 例对照组进行研究。采用视觉评分量表测量壳核低信号的模式，并评分 0-3 分。
81.8%和 54.5%的 11 例 MSA-p 患者分别存在半侧或双侧壳核低信号（评分≥2）和高信号环。MSA-p 患者的壳核低信号评分明显高于其他组（p<0.001），评分≥2 可将 MSA-p 与其他组区分开来。而且，所有 5 例早期疾病阶段的患者也表现出这些特征性发现。
SWI 似乎可用于描绘壳核低信号，甚至在 MSA-p 的早期阶段也如此。这一发现表明，铁沉积相关的壳核变性可能在疾病过程的早期发生。
