Schnur D B, Bernstein A S, Mukherjee S, Loh J, Degreef G, Reidel J
Department of Clinical Neuropsychiatry, New York State Psychiatric Institute, NY 10032.
Schizophr Res. 1989 Nov-Dec;2(6):449-55. doi: 10.1016/0920-9964(89)90013-3.
CT scan measures of prefrontal sulcal prominence, parieto-occipital sulcal prominence, ventricle-brain ratio (VBR), and third ventricle width (TVW) were examined in 24 schizophrenic patients who were grouped on the basis of their autonomic orienting response (OR) status. A two-component definition of the OR was used that required concordance across both electrodermal and finger pulse volume components for response status assignment. The nine OR responders had significantly greater TVW than the 15 OR nonresponders. Although OR responders had higher values also on the other CT scan measures, these differences were not significant. These findings are consistent with the possibility that OR responsiveness and nonresponsiveness are related to different pathological dimensions of schizophrenia.
对24名精神分裂症患者进行了计算机断层扫描（CT）测量，包括前额叶沟突出度、顶枕沟突出度、脑室脑比率（VBR）和第三脑室宽度（TVW），这些患者根据自主定向反应（OR）状态进行分组。采用了OR的双成分定义，即反应状态分配需要皮肤电反应和手指脉搏容积成分两者一致。9名OR反应者的TVW显著大于15名OR无反应者。尽管OR反应者在其他CT扫描测量指标上也有较高值，但这些差异并不显著。这些发现与OR反应性和无反应性与精神分裂症不同病理维度相关的可能性一致。
