Honer W G, Squires-Wheeler E, Smith G N, Sharif Z, Chan S, Gewirtz G
Department of Psychiatry, University of British Columbia, Jack Bell Research Centre, Vancouver, Canada.
Schizophr Res. 1995 Aug 1;16(2):121-5. doi: 10.1016/0920-9964(94)00070-o.
Neurodevelopmental abnormalities and cortical sulcal enlargement both occur in schizophrenia. To test the hypothesis that these abnormalities were related, CT scans from 164 psychotic patients (80 with schizophrenia) were reviewed. Neurodevelopmental abnormalities were observed in 11%. Abnormalities were equally prevalent in schizophrenia and other psychotic disorders. Cortical sulcal enlargement was observed in 39% of patients with schizophrenia, and was not associated with developmental abnormalities. Different mechanisms may contribute to distinct structural abnormalities.
神经发育异常和皮质沟增宽在精神分裂症中均有出现。为了验证这些异常之间存在关联这一假设，我们回顾了164例精神病患者（80例精神分裂症患者）的CT扫描结果。在11%的患者中观察到神经发育异常。这些异常在精神分裂症和其他精神病性障碍中的发生率相当。在39%的精神分裂症患者中观察到皮质沟增宽，且与发育异常无关。不同的机制可能导致不同的结构异常。
