Nanotechnology. 2014 Jun 20;25(24):245103. doi: 10.1088/0957-4484/25/24/245103.
We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.
我们开发了芘基-钆（Py-Gd）纳米粒子作为 pH 敏感的磁共振成像（MRI）对比剂，能够在特定于癌症的环境中显示出高磁共振信号，例如酸性条件下。Py-Gd 纳米粒子是通过使用纳米乳液法用芘基聚乙二醇（PEG）对 Py-Gd（一种与芘基分子形成的复合物）进行包覆而制备的。这些粒子在酸性条件下显示出比中性条件下更好的纵向弛豫时间（T1）MR 信号。此外，这些粒子在体外和体内研究中均表现出良好的生物相容性和磁共振对比效果。从这些结果中，我们证实 Py-Gd 纳米粒子有可能应用于精确的癌症诊断和治疗。
