Worgul B V, Merriam G R, Medvedovsky C
Eye Radiation and Environmental Research Laboratory, Columbia University, New York, NY 10032.
Lens Eye Toxic Res. 1989;6(4):559-71.
Inasmuch as cortical opacities constitute the majority of senile cataracts their pathogenesis has been a matter of investigative concern for over a century. Evidence has been accumulating indicating a primary role for the lens epithelium in the loss of transparency of the cortex. Data from experimental work and clinical experience are consistent with a primary damage to the genome of the lens epithelial cell. The damage is mediated by the aberrant differentiation of lens fiber cells which collectively express as a cataract. The present paper reviews some of that evidence and offers preliminary analysis of the contributing aspects of cellular parameters associated with the pathology. Also, the concept of the "cataractotoxic load" and its applicability to the development of human senile cortical cataracts is discussed.
由于皮质性混浊构成了老年性白内障的大部分，其发病机制在一个多世纪以来一直是研究关注的问题。越来越多的证据表明晶状体上皮在皮质透明度丧失中起主要作用。来自实验研究和临床经验的数据与晶状体上皮细胞基因组的原发性损伤一致。这种损伤是由晶状体纤维细胞的异常分化介导的，这些细胞共同表现为白内障。本文回顾了其中一些证据，并对与该病理学相关的细胞参数的影响因素进行了初步分析。此外，还讨论了“白内障毒性负荷”的概念及其在人类老年性皮质性白内障发展中的适用性。
