Arruzazabala M L, Garcia M
Department of Pharmacology, CENIC, Habana, Cuba.
Arch Immunol Ther Exp (Warsz). 1989;37(5-6):617-20.
Adenosine has controversial effects. The inhalation of this substance causes bronchoconstriction in asthmatic patients, but possesses a protective effect in human inflammatory disease states. We have evaluated the effect of chronic treatment with adenosine (100 micrograms/kg/day), on anaphylactic shock in sensitized mice and guinea pigs and on ozone-induced changes of lung function in rats, taking into account that in these models inflammatory cells and mediators are involved. Adenosine is able to inhibit the increase of wet lung weight to body weight ratio induced by ozone, and to reduce the mortality induced by anaphylactic shock in guinea pigs and mice.
腺苷具有争议性的作用。吸入这种物质会导致哮喘患者支气管收缩，但在人类炎症性疾病状态中具有保护作用。考虑到在这些模型中涉及炎症细胞和介质，我们评估了用腺苷（100微克/千克/天）进行慢性治疗对致敏小鼠和豚鼠过敏性休克以及对大鼠臭氧诱导的肺功能变化的影响。腺苷能够抑制臭氧诱导的肺湿重与体重比的增加，并降低豚鼠和小鼠过敏性休克诱导的死亡率。
